Tandem One-Pot Approach To Access 1,2,3-Triazole-fused Isoindolines through Cu -Catalyzed 1,6-Conjugate Addition of Me3SiN3 to p-Quinone Methides followed by Intramolecular Click Cycloaddition

被引：32

作者：

Jadhav, Abhijeet S. ^{[1
]}

Pankhade, Yogesh A. ^{[1
]}

Anand, Ramasamy Vijaya ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sect 81,Manauli PO, Mohali 140306, Punjab, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 15期

关键词：

AZIDE-ALKYNE CYCLOADDITION; 1,3-DIPOLAR CYCLOADDITION; FUSED 1,2,3-TRIAZOLES; ECONOMICAL ROUTE; TERMINAL ALKYNES; EXPEDIENT ACCESS; SOLID-PHASE; CHEMISTRY; DIVERSE; HETEROCYCLES;

D O I：

10.1021/acs.joc.8b00573

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Cu-catalyzed one-pot approach has been developed for the synthesis of 1,2,3-triazole-fused tricyclic heterocycles. This tandem approach actually involves the 1,6-conjugate addition of Me3SiN3 to o-alkynylated p-quinone methides followed by an intramolecular [3+2]-cycloaddition reaction. This protocol allowed us to access a wide range of 1,2,3-trazole-fused isoindoline derivatives in moderate to good yields.

引用

页码：8596 / 8606

页数：11

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