Advances in Application of Azobenzene as a Trigger in Biomedicine: Molecular Design and Spontaneous Assembly

被引：204

作者：

Cheng, Hong-Bo ^{[1
]}

Zhang, Shuchun ^{[1
]}

Qi, Ji ^{[1
]}

Liang, Xing-Jie ^{[2
,3
]}

Yoon, Juyoung ^{[4
]}

机构：

[1] Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, State Key Lab Organ Inorgan Composites, 15 North Third Ring Rd, Beijing 100029, Peoples R China

[2] Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 First North Rd, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

来源：

ADVANCED MATERIALS | 2021年 / 33卷 / 26期

基金：

中国国家自然科学基金; 新加坡国家研究基金会;

关键词：

azobenzene; biomedicine; bio‐ optical windows; hypoxia; photoswitches; HOST-GUEST INTERACTIONS; CIS-TRANS PHOTOISOMERIZATION; AROMATIC AZO-COMPOUNDS; C-H ACTIVATION; VISIBLE-LIGHT; OPTICAL CONTROL; DRUG-DELIVERY; IN-VIVO; PHOTOCHROMIC PROPERTIES; BLOCK-COPOLYMERS;

D O I：

10.1002/adma.202007290

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Azobenzene is a well-known derivative of stimulus-responsive molecular switches and has shown superior performance as a functional material in biomedical applications. The results of multiple studies have led to the development of light/hypoxia-responsive azobenzene for biomedical use. In recent years, long-wavelength-responsive azobenzene has been developed. Matching the longer wavelength absorption and hypoxia-response characteristics of the azobenzene switch unit to the bio-optical window results in a large and effective stimulus response. In addition, azobenzene has been used as a hypoxia-sensitive connector via biological cleavage under appropriate stimulus conditions. This has resulted in on/off state switching of properties such as pharmacology and fluorescence activity. Herein, recent advances in the design and fabrication of azobenzene as a trigger in biomedicine are summarized.

引用

页数：42

共 341 条

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