Green synthesis of novel quinoxaline sulfonamides with antibacterial activity

被引：28

作者：

Alavi, Sima ^{[1
,2
]}

Mosslemin, Mohammad Hossein ^{[2
]}

Mohebat, Razieh ^{[2
]}

Massah, Ahmad Reza ^{[1
]}

机构：

[1] Islamic Azad Univ, Shahreza Branch, Dept Chem, Shahreza 31186145, Isfahan, Iran

[2] Islamic Azad Univ, Yazd Branch, Dept Chem, Yazd 89195155, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2017年 / 43卷 / 08期

关键词：

Quinoxaline; Catalyst-free; Sulfonamide; Solvent-free; Antibacterial activity; ANTIFUNGAL ACTIVITY; ACID CATALYST; DERIVATIVES; EFFICIENT; INHIBITORS; AGENTS; ANTICANCER;

D O I：

10.1007/s11164-017-2895-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile and efficient method was investigated for the synthesis of different quinoxalines by the reaction of o-phenylene diamine and 2-bromoacetophenones. This procedure was carried out in ethanol under catalyst-free conditions. Several sulfonamides were synthesized from 2-(4-methoxyphenyl)-quinoxaline in two steps. At first chlorosulfonation of 2-(4-methoxyphenyl) quinoxaline was done using chlorosulfonic acid and led to 2-methoxy-5-quinoxalin-2-yl-benzenesulfonyl chloride. Then quinoxaline sulfonamides were synthesized by the reaction of quinoxaline sulfonyl chloride with different aromatic amines under solvent-free conditions. All the products were obtained in excellent yields after an easy work-up and were evaluated for antibacterial activities against Staphylococcus spp. and Escherichia coli bacteria.

引用

页码：4549 / 4559

页数：11

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