Science's Response to CoVID-19

被引：12

作者：

Long, Marcus J. C. ^{[2
]}

Aye, Yimon ^{[1
]}

机构：

[1] Swiss Fed Inst Technol Lausanne EPFL, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne, CH-1015 Lausanne, Switzerland

来源：

CHEMMEDCHEM | 2021年 / 16卷 / 15期

关键词：

NUCLEIC-ACID DETECTION; DISEASE; 2019; COVID-19; SARS-CORONAVIRUS; DRUG DISCOVERY; CORTICOSTEROID TREATMENT; CRYSTAL-STRUCTURE; MOLECULAR-BASIS; SARS-COV-2; INHIBITORS; VIRUS;

D O I：

10.1002/cmdc.202100079

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

CoVID-19 is a multi-symptomatic disease which has made a global impact due to its ability to spread rapidly, and its relatively high mortality rate. Beyond the heroic efforts to develop vaccines, which we do not discuss herein, the response of scientists and clinicians to this complex problem has reflected the need to detect CoVID-19 rapidly, to diagnose patients likely to show adverse symptoms, and to treat severe and critical CoVID-19. Here we aim to encapsulate these varied and sometimes conflicting approaches and the resulting data in terms of chemistry and biology. In the process we highlight emerging concepts, and potential future applications that may arise out of this immense effort.

引用

页码：2288 / 2314

页数：27

共 354 条

[71] Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease [J].

Douangamath, Alice ;

Fearon, Daren ;

Gehrtz, Paul ;

Krojer, Tobias ;

Lukacik, Petra ;

Owen, C. David ;

Resnick, Efrat ;

Strain-Damerell, Claire ;

Aimon, Anthony ;

Abranyi-Balogh, Peter ;

Brandao-Neto, Jose ;

Carbery, Anna ;

Davison, Gemma ;

Dias, Alexandre ;

Downes, Thomas D. ;

Dunnett, Louise ;

Fairhead, Michael ;

Firth, James D. ;

Jones, S. Paul ;

Keeley, Aaron ;

Keserue, Gyoergy M. ;

Klein, Hanna F. ;

Martin, Mathew P. ;

Noble, Martin E. M. ;

O'Brien, Peter ;

Powell, Ailsa ;

Reddi, Rambabu N. ;

Skyner, Rachael ;

Snee, Matthew ;

Waring, Michael J. ;

Wild, Conor ;

London, Nir ;

von Delft, Frank ;

Walsh, Martin A. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[72] Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 [J].

Eastman, Richard T. ;

Roth, Jacob S. ;

Brimacombe, Kyle R. ;

Simeonov, Anton ;

Shen, Min ;

Patnaik, Samarjit ;

Hall, Matthew D. .

ACS CENTRAL SCIENCE, 2020, 6 (05) :672-683

[73] Aspartic proteases in drug discovery [J].

Eder, Joerg ;

Hommel, Ulrich ;

Cumin, Frederic ;

Martoglio, Bruno ;

Gerhartz, Bernd .

CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (03) :271-285

[74] Hydroxychloroquine (HCQ): real treatment or false hope? [J].

El Bakkouri, Karim .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021, 57 (01)

[75] A Direct Method for RT-PCR Detection of SARS-CoV-2 in Clinical Samples [J].

El-Kafrawy, Sherif A. ;

El-Daly, Mai M. ;

Hassan, Ahmed M. ;

Kaki, Reham M. ;

Abuzenadah, Adel M. ;

Kamal, Mohammad A. ;

Azhar, Esam I. .

HEALTHCARE, 2021, 9 (01)

[76] Genomewide Association Study of Severe Covid-19 with Respiratory Failure [J].

Ellinghaus, David ;

Degenhardt, Frauke ;

Bujanda, Luis ;

Buti, Maria ;

Albillos, Agustin ;

Invernizzi, Pietro ;

Fernandez, Javier ;

Prati, Daniele ;

Baselli, Guido ;

Asselta, Rosanna ;

Grimsrud, Marit M. ;

Milani, Chiara ;

Aziz, Fatima ;

Kassens, Jan ;

May, Sandra ;

Wendorff, Mareike ;

Wienbrandt, Lars ;

Uellendahl-Werth, Florian ;

Zheng, Tenghao ;

Yi, Xiaoli ;

de Pablo, Raul ;

Chercoles, Adolfo G. ;

Palom, Adriana ;

Garcia-Fernandez, Alba-Estela ;

Rodriguez-Frias, Francisco ;

Zanella, Alberto ;

Bandera, Alessandra ;

Protti, Alessandro ;

Aghemo, Alessio ;

Lleo, Ana ;

Biondi, Andrea ;

Caballero-Garralda, Andrea ;

Gori, Andrea ;

Tanck, Anja ;

Nolla, Anna Carreras ;

Latiano, Anna ;

Fracanzani, Anna Ludovica ;

Peschuck, Anna ;

Julia, Antonio ;

Pesenti, Antonio ;

Voza, Antonio ;

Jimenez, David ;

Mateos, Beatriz ;

Jimenez, Beatriz Nafria ;

Quereda, Carmen ;

Paccapelo, Cinzia ;

Gassner, Christoph ;

Angelini, Claudio ;

Cea, Cristina ;

Solier, Aurora .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (16) :1522-1534

[77] Nipah virus dynamics in bats and implications for spillover to humans [J].

Epstein, Jonathan H. ;

Anthony, Simon J. ;

Islam, Ariful ;

Kilpatrick, A. Marm ;

Khan, Shahneaz Ali ;

Balkey, Maria D. ;

Ross, Noam ;

Smith, Ina ;

Zambrana-Torrelio, Carlos ;

Tao, Yun ;

Islam, Ausraful ;

Quan, Phenix Lan ;

Olival, Kevin J. ;

Khan, M. Salah Uddin ;

Gurley, Emily S. ;

Hossein, M. Jahangir ;

Field, Hume E. ;

Fielder, Mark D. ;

Briese, Thomas ;

Rahman, Mahmudur ;

Broder, Christopher C. ;

Crameri, Gary ;

Wang, Lin-Fa ;

Luby, Stephen P. ;

Lipkin, W. Ian ;

Daszak, Peter .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (46) :29190-29201

[78] Proteolytic processing of polyproteins 1a and 1ab between non-structural proteins 10 and 11/12 of Coronavirus infectious bronchitis virus is dispensable for viral replication in cultured cells [J].

Fang, Shou Guo ;

Shen, Hongyuan ;

Wang, Jibin ;

Tay, Felicia P. L. ;

Liu, Ding Xiang .

VIROLOGY, 2008, 379 (02) :175-180

[79] Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR [J].

Fang, Yicheng ;

Zhang, Huangqi ;

Xie, Jicheng ;

Lin, Minjie ;

Ying, Lingjun ;

Pang, Peipei ;

Ji, Wenbin .

RADIOLOGY, 2020, 296 (02) :E115-E117

[80] Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma [J].

Farrera-Soler, Lluc ;

Daguer, Jean-Pierre ;

Barluenga, Sofia ;

Vadas, Oscar ;

Cohen, Patrick ;

Pagano, Sabrina ;

Yerly, Sabine ;

Kaiser, Laurent ;

Vuilleumier, Nicolas ;

Winssinger, Nicolas .

PLOS ONE, 2020, 15 (09)

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