Science's Response to CoVID-19

被引:12
作者
Long, Marcus J. C. [2 ]
Aye, Yimon [1 ]
机构
[1] Swiss Fed Inst Technol Lausanne EPFL, CH-1015 Lausanne, Switzerland
[2] Univ Lausanne, CH-1015 Lausanne, Switzerland
关键词
NUCLEIC-ACID DETECTION; DISEASE; 2019; COVID-19; SARS-CORONAVIRUS; DRUG DISCOVERY; CORTICOSTEROID TREATMENT; CRYSTAL-STRUCTURE; MOLECULAR-BASIS; SARS-COV-2; INHIBITORS; VIRUS;
D O I
10.1002/cmdc.202100079
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
CoVID-19 is a multi-symptomatic disease which has made a global impact due to its ability to spread rapidly, and its relatively high mortality rate. Beyond the heroic efforts to develop vaccines, which we do not discuss herein, the response of scientists and clinicians to this complex problem has reflected the need to detect CoVID-19 rapidly, to diagnose patients likely to show adverse symptoms, and to treat severe and critical CoVID-19. Here we aim to encapsulate these varied and sometimes conflicting approaches and the resulting data in terms of chemistry and biology. In the process we highlight emerging concepts, and potential future applications that may arise out of this immense effort.
引用
收藏
页码:2288 / 2314
页数:27
相关论文
共 354 条
[1]   Massively multiplexed nucleic acid detection with Cas13 [J].
Ackerman, Cheri M. ;
Myhrvold, Cameron ;
Thakku, Sri Gowtham ;
Freije, Catherine A. ;
Metsky, Hayden C. ;
Yang, David K. ;
Ye, Simon H. ;
Boehm, Chloe K. ;
Kosoko-Thoroddsen, Tinna-Solveig F. ;
Kehe, Jared ;
Nguyen, Tien G. ;
Carter, Amber ;
Kulesa, Anthony ;
Barnes, John R. ;
Dugan, Vivien G. ;
Hung, Deborah T. ;
Blainey, Paul C. ;
Sabeti, Pardis C. .
NATURE, 2020, 582 (7811) :277-+
[2]   Is the lesser horseshoe bat (Rhinolophus hipposideros) exposed to causes that may have contributed to its decline? A non-invasive approach [J].
Afonso, Eve ;
Tournant, Pierline ;
Foltete, Jean-Christophe ;
Giraudoux, Patrick ;
Baurand, Pierre-Emmanuel ;
Roue, Sebastien ;
Canella, Victoria ;
Vey, Daniele ;
Scheifler, Renaud .
GLOBAL ECOLOGY AND CONSERVATION, 2016, 8 :123-137
[3]   Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases [J].
Ai, Tao ;
Yang, Zhenlu ;
Hou, Hongyan ;
Zhan, Chenao ;
Chen, Chong ;
Lv, Wenzhi ;
Tao, Qian ;
Sun, Ziyong ;
Xia, Liming .
RADIOLOGY, 2020, 296 (02) :E32-E40
[4]   The Impact of the COVID-19 Pandemic on Cancer Patients [J].
Al-Quteimat, Osama M. ;
Amer, Amer Mustafa .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2020, 43 (06) :452-455
[5]   Indicators of Critical Illness and Predictors of in COVID-19 Patients [J].
Aly, Mohamed H. ;
Rahman, Sayed S. ;
Ahmed, Waleed A. ;
Alghamedi, Mansour H. ;
Al Shehri, Abudlrahman A. ;
Alkalkami, Amna M. ;
Hassan, Mohammed H. .
INFECTION AND DRUG RESISTANCE, 2020, 13 :1995-2000
[6]   Mental health of Italian adults during COVID-19 pandemic [J].
Amendola, Simone ;
Spensieri, Valentina ;
Hengartner, Michael P. ;
Cerutti, Rita .
BRITISH JOURNAL OF HEALTH PSYCHOLOGY, 2021, 26 (02) :644-656
[7]  
Anantharajah A., 2020, RES SQ, DOI [10.21203/rs.3.rs-36512/v1, DOI 10.21203/RS.3.RS-36512/V1]
[8]   The proximal origin of SARS-CoV-2 [J].
Andersen, Kristian G. ;
Rambaut, Andrew ;
Lipkin, W. Ian ;
Holmes, Edward C. ;
Garry, Robert F. .
NATURE MEDICINE, 2020, 26 (04) :450-452
[9]  
Anderson S., 2021, INNOV PHARM, V12, P1
[10]  
Andres A.D., 2020, BIORXIV, P2020