Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review

被引：118

作者：

Kamran, Sareh ^{[1
]}

Sinniah, Ajantha ^{[1
]}

Abdulghani, Mahfoudh A. M. ^{[2
]}

Alshawsh, Mohammed Abdullah ^{[1
]}

机构：

[1] Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia

[2] Qassim Univ, Unaizah Coll Pharm, Dept Pharmacol & Toxicol, Al Qassim 51911, Saudi Arabia

来源：

CANCERS | 2022年 / 14卷 / 05期

关键词：

cancer; terpenoids; molecular mechanism; terpenes; chemosensitization; NF-KAPPA-B; CELL-CYCLE ARREST; PROSTATE-CANCER CELLS; ACID INDUCES APOPTOSIS; HUMAN-MELANOMA CELLS; MITOCHONDRIAL-DEPENDENT PATHWAY; URSOLIC ACID; IN-VITRO; D-LIMONENE; ANTITUMOR-ACTIVITY;

D O I：

10.3390/cancers14051100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a life-threatening disease and is considered to be among the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse and metastasis are the major obstacles in cancer therapy. Therefore, introducing new therapeutic agents for cancer remains a priority to increase the range of effective treatments. Terpenoids, a large group of secondary metabolites, are derived from plant sources and are composed of several isoprene units. The high diversity of terpenoids has drawn attention to their potential anticancer and pharmacological activities. Some terpenoids exhibit an anticancer effect by triggering various stages of cancer progression, for example, suppressing the early stage of tumorigenesis via induction of cell cycle arrest, inhibiting cancer cell differentiation and activating apoptosis. At the late stage of cancer development, certain terpenoids are able to inhibit angiogenesis and metastasis via modulation of different intracellular signaling pathways. Significant progress in the identification of the mechanism of action and signaling pathways through which terpenoids exert their anticancer effects has been highlighted. Hence, in this review, the anticancer activities of twenty-five terpenoids are discussed in detail. In addition, this review provides insights on the current clinical trials and future directions towards the development of certain terpenoids as potential anticancer agents.

引用

页数：46

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