Silica sulfuric acid:: an efficient and reusable catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

被引：421
作者：
Salehi, P [1 ]
Dabiri, M
Zolfigol, MA
Fard, MAB
机构：
[1] Shahid Beheshti Univ, Dept Phytochem Aromat & Med Plants, Tehran 1983963113, Iran
[2] Shahid Beheshti Univ, Inst Drug Res, Tehran 1983963113, Iran
[3] Shahid Beheshti Univ, Fac Sci, Dept Chem, Tehran 1983963113, Iran
[4] Bu Ali Sina Univ, Fac Sci, Dept Chem, Hamadan 65174, Iran
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 14期
关键词：
Biginelli reaction; silica sulfuric acid; dihydropyrimidinones; catalysis; solid phase;
D O I：
10.1016/S0040-4039(03)00436-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Silica sulfuric acid efficiently catalyzes the three-component Biginelli reaction between an aldehyde, beta-dicarbonyl compound and urea or thiourea in refluxing ethanol to afford the corresponding dihydropyrinudinones in high yields. The catalyst is reusable and can be applied several times without any decrease in the yield of the reactions. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：2889 / 2891
页数：3
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