Canakinumab treatment in four children with colchicine resistant familial mediterranean fever

被引:0
作者
Ozkan, Solmaz [1 ]
Atas, Bulent
机构
[1] Cumra State Hosp, Cumra, Konya, Turkey
关键词
Familial Mediterranean fever; Anakinra; Canakinumab; EFFICACY;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Familial Mediterranean Fever (FMF) is an autosomal recessive and autoinflammatory disease, characterized with inflammation of serous membranes such as peritoneum, pleura, synovium with fever and pain. Colchicine is the main treatment of FMF, but 5-10 % of patients are unresponsive to colchicine. We report using anti-interleukin-1 agents anakinra and canakinumab in four colchicine-resistant patients who were successfully treated. Three of the patients were siblings.
引用
收藏
页码:945 / 947
页数:3
相关论文
共 10 条
[1]   Efficacy and Safety of Biologic Treatments in Familial Mediterranean Fever [J].
Akgul, Ozgur ;
Kilic, Erkan ;
Kilic, Gamze ;
Ozgocmen, Salih .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2013, 346 (02) :137-141
[2]  
[Anonymous], 2011, PAMUKKALE MED J
[3]   Interleukin-1 targeting treatment in familial Mediterranean fever: an experience of pediatric patients [J].
Basaran, Ozge ;
Uncu, Nermin ;
Celikel, Banu Acar ;
Taktak, Aysel ;
Gur, Gokce ;
Cakar, Nilgun .
MODERN RHEUMATOLOGY, 2015, 25 (04) :621-624
[4]   The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators [J].
Centola, M ;
Wood, G ;
Frucht, DM ;
Galon, J ;
Aringer, M ;
Farrell, C ;
Kingma, DW ;
Horwitz, ME ;
Mansfield, E ;
Holland, SM ;
O'Shea, JJ ;
Rosenberg, HF ;
Malech, HL ;
Kastner, DL .
BLOOD, 2000, 95 (10) :3223-3231
[5]   Familial Mediterranean fever: The genetics of inflammation [J].
Kastner, DL .
HOSPITAL PRACTICE, 1998, 33 (04) :131-+
[6]   Interleukin-1 Targeting Drugs in Familial Mediterranean Fever: A Case Series and a Review of the Literature [J].
Meinzer, Ulrich ;
Quartier, Pierre ;
Alexandra, Jean-Francois ;
Hentgen, Veronique ;
Retornaz, Frederique ;
Kone-Paut, Isabelle .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2011, 41 (02) :265-271
[7]   The efficacy of canakinumab in the treatment of a patient with familial Mediterranean fever and longstanding destructive arthritis [J].
Mitroulis, Ioannis ;
Skendros, Panagiotis ;
Oikonomou, Anastasia ;
Tzioufas, Athanasios G. ;
Ritis, Konstantinos .
ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (07) :1347-1348
[8]   Anti-IL-1 treatment in familial Mediterranean fever and related amyloidosis [J].
Ozcakar, Z. Birsin ;
Ozdel, Semanur ;
Yilmaz, Songul ;
Kurt-Sukur, E. Didem ;
Ekim, Mesiha ;
Yalcinkaya, Fatos .
CLINICAL RHEUMATOLOGY, 2016, 35 (02) :441-446
[9]   Anti-Interleukin 1 Treatment for Patients with Familial Mediterranean Fever Resistant to Colchicine [J].
Ozen, Seza ;
Bilginer, Yelda ;
Ayaz, Nuray Aktay ;
Calguneri, Meral .
JOURNAL OF RHEUMATOLOGY, 2011, 38 (03) :516-518
[10]   Anakinra: New therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine [J].
Roldan, Rosa ;
Ruiz, Adela A. ;
Miranda, Maria D. ;
Collantes, Eduardo .
JOINT BONE SPINE, 2008, 75 (04) :504-505