Ubiquitin-specific peptidase 22 in cancer

被引：34
作者：
Feng, Tingting [1 ,2 ,3 ,4 ]
Ling, Sunbin [4 ]
Xu, Chenyang [1 ]
Ying, Lisha [2 ]
Su, Dan [1 ]
Xu, Xiao [4 ]
机构：
[1] Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC,Dept Pathol,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp,Canc Res Inst,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
[3] Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp,Dept Colorectal Med,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
[4] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Ctr Integrated Oncol & Precis Med, Sch Med,Dept Hepatobiliary & Pancreat Surg, Hangzhou 310006, Peoples R China
来源：
CANCER LETTERS | 2021年 / 514卷
基金：
国家杰出青年科学基金; 中国国家自然科学基金;
关键词：
Deubiquitination; Neoplasms; Cell cycle regulation; Stemness maintenance; Immune microenvironment; EPITHELIAL-MESENCHYMAL TRANSITION; CARCINOMA-CELL-PROLIFERATION; CLASS SWITCH RECOMBINATION; USP22; PROMOTES; HISTONE H2B; HEPATOCELLULAR-CARCINOMA; TRANSCRIPTIONAL ACTIVATION; STRUCTURAL BASIS; POOR-PROGNOSIS; DEUBIQUITINATION;
D O I：
10.1016/j.canlet.2021.05.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently, many studies have shown that deubiquitination modification of proteins is of great significance in major physiological processes such as cell proliferation, apoptosis, and differentiation. The ubiquitin-specific peptidase (USP) family is one of the most numerous and structurally diverse of the deubiquitinates known to date. USP22, an important member of the USP family, has been found to be closely associated with tumor cell cycle regulation, stemness maintenance, invasion and metastasis, chemoresistance, and immune regulation. We focus on recent advances regarding USP22's function in cancer and discuss the prospect of USP22 in this review.
引用
收藏
页码：30 / 37
页数：8
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