Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

被引：366

作者：

Core, Leighton ^{[1
]}

Adelman, Karen ^{[2
]}

机构：

[1] Univ Connecticut, Dept Mol & Cell Biol, Inst Syst Genom, Storrs, CT 06269 USA

[2] Harvard Med Sch, Blavatn Inst, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

GENES & DEVELOPMENT | 2019年 / 33卷 / 15-16期

基金：

美国国家卫生研究院;

关键词：

gene expression; gene regulation; Pol II pausing; transcription regulation; TRANSCRIPTION ELONGATION-FACTOR; CARBOXY-TERMINAL DOMAIN; IMMUNODEFICIENCY-VIRUS TRANSCRIPTION; SENSITIVITY-INDUCING FACTOR; PAUSED POL II; P-TEFB; NASCENT-RNA; NUCLEOSOME ORGANIZATION; R-LOOPS; DROSOPHILA-MELANOGASTER;

D O I：

10.1101/gad.325142.119

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Precise spatio-temporal control of gene activity is essential for organismal development, growth, and survival in a changing environment. Decisive steps in gene regulation involve the pausing of RNA polymerase II (Pol II) in early elongation, and the controlled release of paused polymerase into productive RNA synthesis. Here we describe the factors that enable pausing and the events that trigger Pol II release into the gene. We also discuss open questions in the field concerning the stability of paused Pol II, nucleosomes as obstacles to elongation, and potential roles of pausing in defining the precision and dynamics of gene expression.

引用

页码：960 / 982

页数：23

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