Inflammation: Planning for a Source of Pharmacokinetic/Pharmacodynamic Variability in Translational Studies

被引：22

作者：

Schmith, V. D. ^{[1
]}

Foss, J. F. ^{[2
]}

机构：

[1] GlaxoSmithKline, Dept Clin Pharmacol Modeling & Simulat, Res Triangle Pk, NC 27709 USA

[2] Cleveland Clin, Dept Gen Anesthesiol, Cleveland, OH 44106 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2010年 / 87卷 / 04期

关键词：

DRUG-DISEASE INTERACTIONS; RHEUMATOID-ARTHRITIS; METABOLIZING-ENZYMES; PHARMACOKINETICS; TRANSPORTERS; PROPRANOLOL; PHARMACODYNAMICS; DISPOSITION; EXPRESSION; MEDIATORS;

D O I：

10.1038/clpt.2009.258

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The impact of inflammation on variability in the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs should be considered in the design, analysis, and interpretation of clinical pharmacology studies. Data suggest that the metabolism and transport of drugs, as well as the expression of receptors, may change in the presence of inflammation. The clinical implications of these changes are not straightforward; they may vary depending on whether the inflammation is active or controlled and may change with time and successful treatment of the inflammation.

引用

页码：488 / 491

页数：4

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