Cyclooxygenase-2 polymorphisms in Parkinson's disease

被引:15
作者
Hakansson, Anna
Bergman, Olle
Chrapkowska, Cecilia
Westberg, Lars
Belin, Andrea Carmine
Sydow, Olof
Johnels, Bo
Olson, Lars
Holmberg, Bjorn
Nissbrandt, Hans
机构
[1] Univ Gothenburg, Sahlgrenska Acad, Dept Pharmacol, Inst Neurosci & Physiol, S-40503 Gothenburg, Sweden
[2] Univ Gothenburg, Sahlgrenska Acad, Dept Clin Neurosci & Rehabil, Inst Neurosci & Physiol, S-40503 Gothenburg, Sweden
[3] Karolinska Inst, Dept Neurosci, Stockholm, Sweden
[4] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
关键词
neurodegeneration; inflammation; COX-2; gene;
D O I
10.1002/ajmg.b.30449
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Accumulating evidence indicate that cyclooxygenase-2 (COX-2) is of pathophysiological importance for the neurodegeneration in Parkinson's disease (PD). For example, in a large epidemiological study, use of NSAIDs was associated with a lower risk of PD. Genetic variants of the COX-2 gene might therefore influence the risk of developing the disease. The genotype distribution of four common single nucleotide polymorphisms (SNPs) in the COX-2 gene (rs689466:A496G, rs20417:G926C, rs5277:G3050C, rs5275:C8473T) was analyzed in PD patients and control subjects in a Swedish population. No differences could be seen between the PD-patient and controls regarding the A496G, G926C, and G3050C SNPs, but the allele frequency of the C8473T SNP was found to differ when male patients were compared to controls (P = 0.007). In females no difference could be seen between PD-patients and controls. In conclusion, the results suggest a possible influence of the COX-2 C8473T SNP in PD, although it only seems to be of importance in men. (c) 2006 Wiley-Liss, Inc.
引用
收藏
页码:367 / 369
页数:3
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