Achromatopsia in three sibling Labrador Retrievers in the UK

被引:6
作者
Dixon, Christopher J. [1 ]
机构
[1] Vet Vis Ophthalm Referrals, Onsala Bldg,Ullswater Rd, Penrith CA11 7EH, Cumbria, England
关键词
achromatopsia; CNGB3; gene; day blindness; dog; electroretinography; hemeralopia; CLINICAL ELECTRORETINOGRAPHY; DAY-BLINDNESS; DOGS; HEMERALOPIA; CATARACTS; CNGB3;
D O I
10.1111/vop.12265
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Achromatopsia was identified in three Labrador Retriever littermates. The dogs demonstrated day blindness, negotiating obstacles under low-light conditions, but apparently blind when outdoors. One of the dogs presented with immature bilateral diffuse posterior cortical cataracts and clinical signs of day blindness became apparent following cataract extraction surgery. Electroretinography demonstrated an absence of a cone photoreceptor response to a bright stimulus and a flicker response of 30 Hz in all three dogs. No fundic lesions have been apparent ophthalmoscopically in any of the dogs as the initial presentation of each case. No abnormalities were detected with DNA screening for known mutations of the CNGB3 gene in any of the dogs.
引用
收藏
页码:68 / 72
页数:5
相关论文
共 50 条
[41]   Three-dimensional kinematics of the craniocervical junction of Cavalier King Charles Spaniels compared to Chihuahuas and Labrador retrievers [J].
Nickel, Mareike-Kristin ;
Schikowski, Lisa ;
Fischer, Martin Stephan ;
Kelleners, Nicola ;
Schmidt, Martin Jurgen ;
Eley, Nele .
PLOS ONE, 2023, 18 (01)
[42]   A Novel Movement Disorder in Related Male Labrador Retrievers Characterized by Extreme Generalized Muscular Stiffness [J].
Vanhaesebrouck, A. E. ;
Shelton, G. D. ;
Garosi, L. ;
Harcourt-Brown, T. R. ;
Couturier, J. ;
Behr, S. ;
Harvey, R. J. ;
Jeffery, N. D. ;
Matiasek, K. ;
Blakemore, W. F. ;
Granger, N. .
JOURNAL OF VETERINARY INTERNAL MEDICINE, 2011, 25 (05) :1089-1096
[43]   Comparison of fermentative digestion levels of processed different starch sources by Labrador Retrievers at different ages [J].
Kara, Kanber ;
Guclu, Berrin Kocaoglu ;
Baytok, Erol .
VETERINARNI MEDICINA, 2019, 64 (04) :158-171
[44]   Association between COMT SNP variation and timidity in Golden and Labrador Retrievers [J].
Luo, D. ;
Ma, X. ;
Bai, J. ;
Zhou, Z. ;
Wang, F. ;
Wang, A. ;
Wang, J. .
ANIMAL GENETICS, 2018, 49 (04) :340-344
[45]   The impact of the COVID-19 pandemic on a cohort of Labrador retrievers in England [J].
Charlotte S. C. Woolley ;
Ian G. Handel ;
B. Mark Bronsvoort ;
Jeffrey J. Schoenebeck ;
Dylan N. Clements .
BMC Veterinary Research, 18
[46]   Comparative anatomy of the proximal tibia in healthy Labrador Retrievers and Yorkshire Terriers [J].
Vedrine, B. ;
Guillemot, A. ;
Fontaine, D. ;
Ragetly, G. R. ;
Etchepareborde, S. .
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY, 2013, 26 (04) :266-270
[47]   Canine POMC deletion (P187fs) allele frequency in Labrador Retrievers in Brazil [J].
Lourenco, Natalia O. ;
Albuquerque, Ana Luisa H. ;
Basso, Roberta M. ;
Trecenti, Anelize S. ;
Albertino, Lukas G. ;
Melchert, Alessandra ;
Borges, Alexandre S. ;
Oliveira-Filho, Jose P. .
PESQUISA VETERINARIA BRASILEIRA, 2019, 39 (11) :909-914
[48]   Serum miR-30b is increased in Labrador Retrievers with elevated hepatic copper levels [J].
Roelen, Yara S. ;
Spee, Bart ;
van Wolferen, Monique E. ;
Fieten, Hille ;
den Boer, Elise R. .
VETERINARY JOURNAL, 2025, 311
[49]   Intragenic PNPLA1 duplication in Labrador retrievers with nonepidermolytic ichthyosis [J].
Rietmann, Stefan J. ;
Clegg, Jennifer L. ;
Jagannathan, Vidhya ;
Wiener, Dominique J. ;
Kallenberg, Angelica ;
Grahn, Robert A. ;
Souza, Clarissa P. ;
Leeb, Tosso .
VETERINARY DERMATOLOGY, 2025, :314-320
[50]   L-Carnitine metabolism, protein turnover and energy expenditure in supplemented and exercised Labrador Retrievers [J].
Varney, Jessica Lyn ;
Fowler, Jason William ;
McClaughry, Trenda Clarice ;
Vignale, Karen ;
Caldas, Justina ;
Weil, Jordan Taylor ;
Coon, Craig Nelson .
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 2020, 104 (05) :1540-1550