Synthesis and Anticancer evaluation of (-)-Arctigenin Derivatives

被引：0

作者：

Xu, Yubin ^{[1
]}

Chen, Guirong ^{[1
]}

Dou, Deqiang ^{[1
]}

Jiang, Hongshuai ^{[1
]}

Kang, Tingguo ^{[1
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2014年 / 36卷 / 05期

关键词：

(-)-Arctigenin; Synthesis; Synthetic derivatives; Anticancer activity; LIGNANS; AGENTS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Seven (-)-arctigenin derivatives 1-7 were designed and synthesized by using Mannich and acylation methods to improve the activity and bioavailability of (-)-arctigenin. Structures of compounds 1-7 were elucidated on the basis of spectroscopic analysis and chemical evidence. Anticancer activity of these compounds on SGC7901 was assayed in vitro.

引用

页码：870 / 874

页数：5

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