Clinical value of integrated-signature miRNAs in esophageal cancer

被引：19

作者：

Zhang, Heng-Chao ^{[1
,2
]}

Tang, Kai-Fu ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Inst Translat Med, Wenzhou 325015, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Digest Canc Ctr, Wenzhou 325015, Zhejiang, Peoples R China

来源：

CANCER MEDICINE | 2017年 / 6卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Enrichment analysis; esophageal cancer; miRNA biomarker; prognosis; SQUAMOUS-CELL CARCINOMA; DIFFERENTIAL EXPRESSION; BARRETTS-ESOPHAGUS; DOWN-REGULATION; MICRORNA SIGNATURE; SERUM; PROGRESSION; PROFILES; INVASION; GENES;

D O I：

10.1002/cam4.1129

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated-miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa-miR-100-5p and hsa-miR-133b) show better prognoses with significant difference for both 3-year and 5-year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer.

引用

页码：1893 / 1903

页数：11

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