Metal-Free Three-Component Oxyalkynylation of Alkenes

被引：26
|
作者：
Li, Yangshan [1 ]
Lu, Ran [1 ]
Sun, Shutao [1 ]
Liu, Lei [1 ,2 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 21期
基金：
美国国家科学基金会;
关键词：
NUCLEOPHILE-OLEFIN COMBINATION; AROMATIC-SUBSTITUTION REACTION; ANTI-MARKOVNIKOV ADDITION; PHOTOCHEMICAL NUCLEOPHILE; ACIDS; DIFUNCTIONALIZATION; EFFICIENT; RADICALS; ALCOHOLS; STYRENES;
D O I：
10.1021/acs.orglett.8b02954
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented (NH4)(2)S2O8 mediated metal-free three-component alkene oxyalkynylation using H2O or alcohol as oxygenation agent is described. Mechanistic studies suggested that the reversed regioselectivity should be dictated by an alkene radical cation intermediate.
引用
收藏
页码：6836 / 6839
页数：4
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