Monolayer grafting of aminosilane on magnetic nanoparticles: An efficient approach for targeted drug delivery system

被引：55

作者：

Dhavale, R. P. ^{[1
,4
]}

Waifalkar, P. P. ^{[2
]}

Sharma, Apoorva ^{[3
]}

Dhavale, R. P. ^{[1
,4
]}

Sahoo, Subasa C. ^{[5
]}

Kollu, P. ^{[6
,7
]}

Chougale, A. D. ^{[8
]}

Zahn, D. R. T. ^{[3
]}

Salvan, G. ^{[3
]}

Patil, P. S. ^{[1
,2
]}

Patil, P. B. ^{[9
]}

机构：

[1] Shivaji Univ, Sch Nanosci & Technol, Kolhapur 416004, Maharashtra, India

[2] Shivaji Univ, Dept Phys, Kolhapur 416004, Maharashtra, India

[3] Tech Univ Chemnitz, Inst Phys, D-09107 Chemnitz, Germany

[4] Bharati Vidyapeeth, Dept Pharmaceut, Coll Pharm, Kolhapur 416013, Maharashtra, India

[5] Cent Univ Kerala, Dept Phys, Kasaragod 671314, Kerala, India

[6] Univ Hyderabad, Sch Phys, CASEST, Hyderabad 500046, Telangana, India

[7] Univ Cambridge, Dept Phys, Cavendish Lab, Thin Film Magnetism Grp, Cambridge CB3 0HE, England

[8] Shivaji Univ, Dept Chem, New Coll, Kolhapur 416012, Maharashtra, India

[9] Shivaji Univ, Dept Phys, New Coll, Kolhapur 416012, Maharashtra, India

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2018年 / 529卷

关键词：

Magnetic nanoparticles (MNP); Functionalization; Targeted drug delivery; APTES; Monolayer grafting; FORC; Telmisartan; IRON-OXIDE NANOPARTICLES; MODIFIED SUPERPARAMAGNETIC NANOPARTICLES; CORE-SHELL NANOPARTICLES; REVERSAL CURVE DIAGRAMS; CONTROLLED-RELEASE; IN-VITRO; CANCER; PH; FUNCTIONALIZATION; MECHANISMS;

D O I：

10.1016/j.jcis.2018.06.006

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Magnetic nanoparticles (MNPs) with higher magnetization are highly desirable for targeted drug delivery (TDD) systems, as it helps accumulation of drug at the target site. However, functionalization of MNPs for drug binding reduces the magnetization which affects the efficacy of TDD. Herein we report direct functionalization of MNPs with (3-Aminopropyl)triethoxysilane (APTES) which preserves the magnetization. Grafting density estimated by TGA and BET analysis showed monolayer grafting of APTES on MNP surface. MNPs were comprehensively characterized by XRD, HR-TEM, SQUID-VSM and FTIR. Anti cancerous drug telmisartan (TEL) was loaded on monolayer APTES grafted MNPs. In-vitro controlled drug release and cytotoxicity study on PC-3 human prostate cancer cell line of TEL conjugated MNPs are also discussed. This functionalization strategy can be extended to other biomedical applications where higher magnetization is desired. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：415 / 425

页数：11

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