Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities

被引：38

作者：

Chang, LC

Gills, JJ

Bhat, KPL

Luyengi, L

Farnsworth, NR

Pezzuto, JM

Kinghorn, AD ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(00)00477-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new cardenolides, (-)-14-hydroxy-3 beta-(3-O-methyl-6-deoxy-alpha -L-rhamnosyl)-11 alpha ,12 alpha -epoxy-(5 beta ,14 beta ,17 betaH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3 beta-(3-O-methyl-6-deoxy-alpha -L-glucopyranosyl)-11 alpha ,12 alpha -epoxy-(5 beta ,14 beta ,1 7 betaH)-card-20(22)-enolide (2), and a known cardenolide, (-)-17 beta -neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and antiestrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2431 / 2434

页数：4

共 29 条

[1] CERBERA .7. SESQUI-LIGNAN, SESTER-LIGNAN AND TRILIGNAN FROM STEMS OF CERBERA-MANGHAS AND CERBERA-ODOLLAM [J].