C75 inhibits food intake by increasing CNS glucose metabolism

被引:55
作者
Wortman, MD [1 ]
Clegg, DJ
D'Alessio, D
Woods, SC
Seeley, RJ
机构
[1] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45221 USA
[2] Univ Cincinnati, Coll Med, Dept Endocrinol, Cincinnati, OH USA
关键词
D O I
10.1038/nm0503-483
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:483 / 485
页数:4
相关论文
共 8 条
[1]   Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion [J].
Clegg, DJ ;
Wortman, MD ;
Benoit, SC ;
McOsker, CC ;
Seeley, RJ .
DIABETES, 2002, 51 (11) :3196-3201
[2]   Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment [J].
Kim, EK ;
Miller, I ;
Landree, LE ;
Borisy-Rudin, FF ;
Brown, P ;
Tihan, T ;
Townsend, CA ;
Witters, LA ;
Moran, TH ;
Kuhajda, FP ;
Ronnett, GV .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 283 (05) :E867-E879
[3]   Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice [J].
Kumar, MV ;
Shimokawa, T ;
Nagy, TR ;
Lane, MD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :1921-1925
[4]   Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors [J].
Loftus, TM ;
Jaworsky, DE ;
Frehywot, GL ;
Townsend, CA ;
Ronnett, GV ;
Lane, MD ;
Kuhajda, FP .
SCIENCE, 2000, 288 (5475) :2379-2381
[5]   Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting [J].
Makimura, H ;
Mizuno, TM ;
Yang, XJ ;
Silverstein, J ;
Beasley, J ;
Mobbs, CV .
DIABETES, 2001, 50 (04) :733-739
[6]   Central administration of oleic acid inhibits glucose production and food intake [J].
Obici, S ;
Feng, ZH ;
Morgan, Y ;
Stein, D ;
Karkanias, G ;
Rossetti, L .
DIABETES, 2002, 51 (02) :271-275
[7]   Malonyl-CoA, fuel sensing, and insulin resistance [J].
Ruderman, NB ;
Saha, AK ;
Vavvas, D ;
Witters, LA .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 276 (01) :E1-E18
[8]   Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides [J].
Shimokawa, T ;
Kumar, MV ;
Lane, MD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) :66-71