The influence of surface coatings on the toxicity of silver nanoparticle in rainbow trout

被引：23

作者：

Auclair, J. ^{[1
]}

Turcotte, P. ^{[1
]}

Gagnon, C. ^{[1
]}

Peyrot, C. ^{[1
]}

Wilkinson, K. J. ^{[1
]}

Gagne, F. ^{[1
]}

机构：

[1] Environm & Climate Change Canada, Aquat Contaminants Res Div, 105 McGill, Montreal, PQ H2Y 2E7, Canada

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 2019年 / 226卷

关键词：

Silver nanoparticles; Coatings; Inflammation; Genotoxicity; PARTICLE-SIZE; WASTE-WATER; NANOMATERIALS; EXPOSURE; METALS; MUSSEL; CHARGE; DNA; AG;

D O I：

10.1016/j.cbpc.2019.108623

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Silver nanoparticles (nAg) are often produced with different coatings that could influence bioavailability and toxicity in aquatic organisms. The purpose of this study was to examine the influence of 4 surface coatings of nAg of the same core size towards bioavailability and toxicity in juvenile rainbow trout (Oncorhynchus mykiss). Juveniles were exposed to 50 mu g/L of 50 nm diameter nAg for 96 hat 15 degrees C with the following coatings: branched polyethylenimine (bPEI), citrate, polyvinylpyrrolidone (PVP) and silicate (Si). The data revealed that the coatings influenced hepatic Ag loadings in the following trend PVP > citrate > bPEI and Si with estimated bioavailability factors of 28, 18, 6 and 2 L/kg respectively. Hepatic Ag levels were significantly associated with DNA damage and inflammation as determined by arachidonate cyclooxygenase activity. The bPEI and citrate-coated nAg consistently produced the observed effects above in addition to increased mitochondrial electron transport activity and glutathione S-transferase activity. The absence of metallothionein and lipid peroxidation suggests that mechanisms other than the liberation of Ag+ were at play. In conclusion, surface coatings were shown to significantly influence bioavailability and toxic properties of nAg to rainbow trout juveniles.

引用

页数：8

共 32 条

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