Novel Tween® 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma

被引：20

作者：

Masotti, Andrea ^{[1
]}

Vicennati, Paola ^{[2
]}

Alisi, Anna ^{[3
]}

Marianecci, Carlotta ^{[4
]}

Rinaldi, Federica ^{[4
]}

Carafa, Maria ^{[4
]}

Ortaggi, Giancarlo ^{[2
]}

机构：

[1] IRCCS Childrens Hosp Bambino Gesu, Gene Express Microarrays Lab, I-00165 Rome, Italy

[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[3] IRCCS Childrens Hosp Bambino Gesu, Liver Unit, I-00165 Rome, Italy

[4] Univ Roma La Sapienza, Dept Chim & Tecnol Farmaco, Fac Pharm, I-00185 Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 10期

关键词：

Tween (R) 20; pH-sensitive vesicles; Drug delivery systems; Hepatoblastoma; NON-PHOSPHOLIPID VESICLE; SURFACTANT VESICLES; LIVER-TUMORS; LIPOSOMES; POLYSORBATE-20; NIOSOMES;

D O I：

10.1016/j.bmcl.2010.04.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe the synthesis, the physicochemical characterization and the biological evaluation of three novel pH-sensitive systems prepared derivatizing polysorbate 20 (Tween (R) 20) with glycine, N-methylglycine and N,N-dimethyl-glycine (TW20-GLY, TW20-MMG and TW20-DMG). These derivatives form pH-sensitive vesicles and translocate small molecules into cells. The reported systems are efficient drug delivery systems for human hepatoblastoma cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3021 / 3025

页数：5

共 5 条

[1] Novel pH-sensitive non-ionic surfactant vesicles: comparison between Tween 21 and Tween 20
Di Marzio, Luisa
Marianecci, Carlotta
Petrone, Mariadea
Rinaldi, Federica
Carafa, Maria
COLLOIDS AND SURFACES B-BIOINTERFACES, 2011, 82 (01) : 18 - 24
[2] pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method
Laouini, Abdallah
Koutroumanis, Konstantinos P.
Charcosset, Catherine
Georgiadou, Stella
Fessi, Hatem
Holdich, Richard G.
Vladisavljevic, Goran T.
ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (18) : 8939 - 8947
[3] Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy
Xie, Jiajiang
Fan, Zhongxiong
Li, Yang
Zhang, Yinying
Yu, Fei
Su, Guanghao
Xie, Liya
Hou, Zhenqing
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 : 1381 - 1398
[4] Formulation optimization of pH-sensitive liposomes based drug delivery of Carboplatin and anti-proliferative evaluation against A549 (human lung carcinoma) cell lines
Aneja, Preeti
Negi, Prabhat
Aneja, Shivali
Garad, Suyog Rajendra
Kumar, Sunil
MAIN GROUP CHEMISTRY, 2023, 22 (03) : 403 - 421
[5] Novel ionically crosslinked acrylamide-grafted poly(vinyl alcohol)/sodium alginate/sodium carboxymethyl cellulose pH-sensitive microspheres for delivery of Alzheimer's drug donepezil hydrochloride: Preparation and optimization of release conditions
Bulut, Emine
Sanli, Oya
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2016, 44 (02) : 431 - 442

← 1 →