Microbiome: Effects of Ageing and Diet

被引：50

作者：

Salazar, Nuria ^{[1
,2
]}

Gonzalez, Sonia ^{[2
,3
]}

Nogacka, Alicja M. ^{[1
,2
]}

Rios-Covian, David ^{[1
,2
]}

Arboleya, Silvia ^{[1
,2
]}

Gueimonde, Miguel ^{[1
,2
]}

de los Reyes-Gavilan, Clara G. ^{[1
,2
]}

机构：

[1] CSIC, IPLA, Spanish Res Council, Dept Microbiol & Biochem Dairy Prod, Villaviciosa, Spain

[2] Inst Invest Sanitaria Principado Asturias, ISPA, Diet Microbiota & Hlth Res Team, Oviedo, Spain

[3] Univ Oviedo, Fac Med, Dept Funct Biol, Oviedo, Spain

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2020年 / 36卷

关键词：

CLOSTRIDIUM-DIFFICILE INFECTION; BUTYRATE-PRODUCING BACTERIA; POLYMERASE-CHAIN-REACTION; MIXTURE B-GOS; GUT MICROBIOTA; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; BIFIDOBACTERIUM-BIFIDUM; IMMUNE PARAMETERS; GASTRIC-MUCOSA;

D O I：

10.21775/cimb.036.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microbial community inhabiting our intestine, known as 'microbiota', and the ensemble of their genomes (microbiome) regulate important functions of the host, being essential for health maintenance. The recent development of next-generation sequencing (NGS) methods has greatly facilitated the study of the microbiota and has contributed to evidence of the strong influence exerted by age and diet. However, the precise way in which the diet and its components modify the functionality of the intestinal microbiome is far from being completely known. Changes in the intestinal microbiota occur during ageing, frequently accompanied by physiological changes of the digestive tract, modification of dietary patterns and impairment of the immune system. Establishing nutritional strategies aiming to counterbalance the specific alterations taking place in the microbiota during ageing would contribute to improved health status in the elderly. This review will analyse changes appearing in the intestinal microbiota from adulthood to old age and their association with dietary patterns and lifestyle factors.

引用

页码：33 / 61

页数：29

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