Clinical significance of high nm23-H1 expression in Intraepithelial neoplasia and early-stage squamous cell carcinoma of the uterine cervix

被引：10
作者：
Wang, PH
Ko, JL
Chang, H
Lin, LY
机构：
[1] Chung Shan Med Univ Hosp, Dept Obstet & Gynecol, Taichung 40201, Taiwan
[2] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[3] Chung Shan Med Univ, Dept Pathol, Taichung, Taiwan
[4] Chung Shan Med Univ, Inst Toxicol, Taichung, Taiwan
来源：
GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2003年 / 55卷 / 01期
关键词：
high nm23-H1 expression; high-grade cervical intraepithelial neoplasia cellular proliferation; squamous cell carcinoma; deep stromal invasion; cumulative recurrence hazard;
D O I：
10.1159/000068951
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Seventy-two cervical pathology specimens, consisting of samples of cancer and high- and low-grade intraepithelial neoplasia, were used in a study exploring the involvement of nm23-H1/NDP kinase in carcinogenesis or recurrence. Additionally, the relationships between immunohistochemical expression of nm23-H1 and various clinicopathological variables for early-stage cervical cancer were evaluated. The nm23-H1 expression for high-grade cervical intraepithelial neoplasia and squamous cell carcinoma samples was significantly elevated when compared to low-grade analogs. Only deep stromal invasion was significantly associated with high nm23 expression. Moreover, a high cumulative recurrence hazard was demonstrated for the high nm23 expression group. In conclusion, high nm23-H1 expression may induce cellular proliferation for the progression from low- to high-grade intraepithelial neoplasia, with the subsequent emergence of invasive carcinoma as well as deep stromal invasion, and can be used as an indicator of prognosis. Copyright (C) 2003 S. KargerAG, Basel.
引用
收藏
页码：14 / 19
页数：6
相关论文
共 23 条
[1]  
BEVILACQUA G, 1989, CANCER RES, V49, P5185
[2]   Prognostic value of nm23 expression in stage IB1 cervical carcinoma [J].
Chen, HY ;
Hsu, CT ;
Lin, WC ;
Tsai, HD ;
Chang, WC .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2001, 31 (07) :327-332
[3]   HIGH-LEVELS OF NM23-H1 AND NM23-H2 MESSENGER-RNA IN HUMAN SQUAMOUS-CELL LUNG-CARCINOMA ARE ASSOCIATED WITH POOR DIFFERENTIATION AND ADVANCED TUMOR STAGES [J].
ENGEL, M ;
THEISINGER, B ;
SEIB, T ;
SEITZ, G ;
HUWER, H ;
ZANG, KD ;
WELTER, C ;
DOOLEY, S .
INTERNATIONAL JOURNAL OF CANCER, 1993, 55 (03) :375-379
[4]  
FLORENES VA, 1992, CANCER RES, V52, P6088
[5]  
GILLES AM, 1991, J BIOL CHEM, V266, P8784
[6]   INDUCTION OF NM23 GENE-EXPRESSION IN HUMAN COLONIC NEOPLASMS AND EQUAL EXPRESSION IN COLON TUMORS OF HIGH AND LOW METASTATIC POTENTIAL [J].
HAUT, M ;
STEEG, PS ;
WILLSON, JKV ;
MARKOWITZ, SD .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (10) :712-716
[7]  
KIKKAWA S, 1990, J BIOL CHEM, V265, P21536
[8]   EXPRESSION OF NM23-H1 AND NM23-H2 PROTEINS IN PROSTATE CARCINOMA [J].
KONISHI, N ;
NAKAOKA, S ;
TSUZUKI, T ;
MATSUMOTO, K ;
KITAHORI, Y ;
HIASA, Y ;
URANO, T ;
SHIKU, H .
JAPANESE JOURNAL OF CANCER RESEARCH, 1993, 84 (10) :1050-1054
[9]   Evaluation of the prognostic significance of nm23/NDP kinase protein expression in cervical carcinoma: An immunohistochemical study [J].
Kristensen, GB ;
Holm, R ;
Abeler, VM ;
Trope, CG .
GYNECOLOGIC ONCOLOGY, 1996, 61 (03) :378-383
[10]   OVEREXPRESSION OF NUCLESIDE DIPHOSPHATE KINASE (NM23) IN SOLID TUMORS [J].
LACOMBE, ML ;
SASTREGARAU, X ;
LASCU, I ;
VONICA, A ;
WALLET, V ;
THIERY, JP ;
VERON, M .
EUROPEAN JOURNAL OF CANCER, 1991, 27 (10) :1302-1307
123