Zolpidem Use and Suicide Death in South Korea: A Population-Based Case-Control Study

被引：9

作者：

Choi, BongKyoo ^{[1
,2
]}

Sung, Hi Gin ^{[3
]}

Nam, Jin Hyun ^{[3
]}

Shin, Ju-Young ^{[3
]}

机构：

[1] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA

[2] Univ Calif Irvine, Program Publ Hlth, Irvine, CA USA

[3] Sungkyunkwan Univ, Sch Pharm, 2066 Seobu Ro, Suwon, Gyeonggi Do, South Korea

来源：

SUICIDE AND LIFE-THREATENING BEHAVIOR | 2019年 / 49卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1111/sltb.12548

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective To investigate whether zolpidem use is associated with suicide death in adults. Method We conducted a case-control study using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database. Cases were adults with a suicide record (ICD-10 codes; X-60-X84, Y87.0) between January 1, 2004 and December 31, 2013. 10 Controls were matched to each case by age, sex, index year, region, income level, and health insurance type. Zolpidem use during 2 years before suicide was quantified. Adjusted odd ratios (aORs) with 95% confidence intervals (CIs) were estimated using conditional logistic regression. Results The percentage of zolpidem users was significantly higher in cases (451 of 1,928 [23.4%]) than in controls (832 of 18,404 [4.5%]). After controlling for potential confounders, zolpidem use was significantly associated with suicide (aORs, 2.09; 95% CI, 1.74-2.52). Dose-response relationships were observed (for trend, p < .0001). Consistent findings were observed when analyses were restricted to suicide death (aORs, 2.08; 95% CI, 1.73-2.51) and nonmedication poisoning suicide death cases (aORs, 2.10; 95% CI, 1.74-2.53). Conclusions We found a significant and positive association between zolpidem use and suicide. Zolpidem should be prescribed cautiously and with due caution of increased suicide risk.

引用

页码：1653 / 1667

页数：15

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