Gold Nanoparticles for Biology and Medicine

被引：1977
作者：
Giljohann, David A. [1 ,2 ]
Seferos, Dwight S. [1 ,2 ]
Daniel, Weston L. [1 ,2 ]
Massich, Matthew D. [1 ,2 ]
Patel, Pinal C. [1 ,2 ]
Mirkin, Chad A. [1 ,2 ]
机构：
[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
[2] Northwestern Univ, Int Inst Nanotechnol, Evanston, IL 60208 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 19期
关键词：
cytotoxicity; DNA; drug delivery; gold; nanoparticles; MESSENGER-RNA DETECTION; LOCKED NUCLEIC-ACID; SURFACE-PLASMON RESONANCE; GENE DELIVERY; ANTISENSE OLIGONUCLEOTIDES; MOLECULAR BEACONS; CELLULAR UPTAKE; NANO-FLARES; ULTRASENSITIVE DETECTION; OPTICAL-PROPERTIES;
D O I：
10.1002/anie.200904359
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Gold colloids have fascinated scientists for over a century and are now heavily utilized in chemistry, biology, engineering, and medicine. Today these materials can be synthesized reproducibly, modified with seemingly limitless chemical functional groups, and, in certain cases, characterized with atomic-level precision. This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates. There are now many examples of highly sensitive and selective assays based upon gold nanoconjugates. In recent years, focus has turned to therapeutic possibilities for such materials. Structures which behave as gene-regulating agents, drug carriers, imaging agents, and photoresponsive therapeutics have been developed and studied in the context of cells and many debilitating diseases. These structures are not simply chosen as alternatives to molecule-based systems, but rather for their new physical and chemical properties, which confer substantive advantages in cellular and medical applications. © 2010 wiley-vch verlag gmbh &. Co. KgaA.
引用
收藏
页码：3280 / 3294
页数：15
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