Convenient catalytic, enantioselective conjugate reduction of nitroalkenes using CuF2

被引：83

作者：

Czekelius, C ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] ETH Honggerberg, ETH Zurich, Organ Chem Lab, HCI, CH-8093 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 24期

关键词：

D O I：

10.1021/ol048035h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] We document the use of a new catalyst system for the enantioselective conjugate reduction of nitroalkenes utilizing commercially available CuF2 and the bis-phosphine JOSIPHOS as a ligand. This new protocol not only facilitates ready access to a variety of optically active nitroalkanes, but the results provide also new insight into copper-catalyzed reactions.

引用

页码：4575 / 4577

页数：3

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