Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area

被引：4

作者：

Gavrilov, Yury V. ^{[1
,2
,3
]}

Ellison, Brian A. ^{[1
]}

Yamamoto, Mihoko ^{[1
]}

Reddy, Hasini ^{[4
]}

Haybaeck, Johannes ^{[5
]}

Mignot, Emmanuel ^{[6
]}

Baumann, Christian R. ^{[1
,2
]}

Scammell, Thomas E. ^{[1
]}

Valko, Philipp O. ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[2] Univ Zurich, Univ Zurich Hosp, Dept Neurol, Frauenklinikstr 26, CH-8091 Zurich, Switzerland

[3] Inst Expt Med, Dept Gen Pathol & Pathol Physiol, St Petersburg, Russia

[4] Beth Israel Deaconess Med Ctr, Dept Neuropathol, Boston, MA 02215 USA

[5] Med Univ Graz, Inst Pathol, Dept Neuropathol, Graz, Austria

[6] Stanford Univ, Ctr Narcolepsy, Dept Psychiat, Palo Alto, CA 94304 USA

来源：

SLEEP | 2016年 / 39卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

galanin; narcolepsy; sleep fragmentation; ventrolateral preoptic area; REM-SLEEP; NIGHTTIME SLEEP; NUCLEUS; CATAPLEXY; HYPOTHALAMUS; NUMBERS;

D O I：

10.5665/sleep.5754

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Objectives: To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. Methods: Postmortem examination of five narcolepsy and eight control brains. Results: VLPO galanin neuron count did not differ between narcolepsy patients (11,151 +/- 3,656) and controls (13,526 +/- 9,544). Conclusions: A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.

引用

页码：1059 / 1062

页数：4

共 27 条

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[22] Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism
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[26] Effects of gamma-aminobutyric acid A-receptor antagonist on sleep-wakefulness cycles following lesion to the ventrolateral preoptic area in rats
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[27] GABAergic neurons with α2-adrenergic receptors in basal forebrain and preoptic area express c-Fos during sleep
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