Phase I dose escalation study of amrubicin plus paclitaxel in previously treated advanced non-small cell lung cancer
被引:3
|
作者:
Kaira, Kyoichi
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机构:
Gunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Kaira, Kyoichi
[1
,2
]
Sunaga, Noriaki
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机构:
Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Sunaga, Noriaki
[2
]
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Imai, Hisao
[2
]
Kamide, Yosuke
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机构:
Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Kamide, Yosuke
[2
]
Koga, Yasuhiko
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Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Koga, Yasuhiko
[2
]
Ono, Akihiro
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Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Ono, Akihiro
[2
]
Kuwako, Tomohito
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Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Kuwako, Tomohito
[2
]
Masuda, Tomomi
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Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Masuda, Tomomi
[2
]
Hisada, Takeshi
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机构:
Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Hisada, Takeshi
[2
]
Ishizuka, Tamotsu
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Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, Japan
Univ Fukui, Fac Med Sci, Dept Internal Med 3, Fukui 910, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Ishizuka, Tamotsu
[2
,3
]
Yamada, Masanobu
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Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, JapanGunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
Yamada, Masanobu
[2
]
机构:
[1] Gunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan
[2] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, Japan
[3] Univ Fukui, Fac Med Sci, Dept Internal Med 3, Fukui 910, Japan
Amrubicin;
Paclitaxel;
NSCLC;
Phase I;
Topoisomerase II;
Class III beta-tubulin;
BREAST-CANCER;
EXPRESSION;
ALPHA;
9-AMINOANTHRACYCLINE;
CHEMOTHERAPY;
PLATINUM;
SURVIVAL;
TRIAL;
VITRO;
D O I:
10.1007/s10147-015-0883-7
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
We conducted a phase I dose escalation study to determine the maximum tolerated dose (MTD), the recommended dose (RD) and the safety profile of amrubicin (AMR) plus paclitaxel (PTX) combination regimen for patients with previously treated non-small cell lung cancer (NSCLC). PTX was administered at a fixed dose of 150 mg/m(2)/day on day 1 and AMR was intravenously administered at a starting dose of 25 mg/m(2)/day on days 1-3, and this was repeated every 4 weeks. Doses of each drug were planned as follows-level 0, 20/150; level 1, 25/150; level 2, 30/150; level 3, 30/180 AMR mg/m(2) per day/PTX mg/m(2) per day. Twelve patients were enrolled in this study. The dose-limiting toxicity (DLT) of the regimen was assessed during the first cycle. At level 1, all three patients developed a DLT due to grade 4 neutropenia lasting > 4 days, grade 4 thrombocytopenia and grade 3 febrile neutropenia. Therefore, level 1 was considered the MTD and level 0 was selected as the RD. Objective responses were seen in two patients (response rate 16.7 %). Overall disease control rate was 91.7 %. The combination of AMR and PTX is a feasible and well-tolerated regimen for the treatment of patients with previously treated advanced NSCLC. Although our study included a small number of patients, encouraging disease control and progression-free survival were achieved at the recommended doses. Further clinical trials are warranted.
机构:
Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Gerber, David E.
Skelton, Rachael
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Skelton, Rachael
Dong, Ying
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Dong, Ying
Loudat, Laurin
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Loudat, Laurin
Dowell, Jonathan
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Dowell, Jonathan
Boothman, David A.
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Boothman, David A.
Sarode, Venetia
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Sarode, Venetia
Zhang, Wei
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Zhang, Wei
Xie, Yang
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Xie, Yang
Gazdar, Adi
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Gazdar, Adi
Frenkel, Eugene P.
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
Frenkel, Eugene P.
Schiller, Joan H.
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Univ Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA
机构:
Kitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Otani, Sakiko
Sasaki, Jiichiro
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Kitasato Univ, Sch Med, Res & Dev Ctr New Med Frontiers, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Sasaki, Jiichiro
Nakahara, Yoshiro
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Kitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Nakahara, Yoshiro
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Fukui, Tomoya
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Igawa, Satoshi
Naoki, Katsuhiko
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机构:
Kitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Naoki, Katsuhiko
Bessho, Akihiro
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机构:
Japanese Red Cross Okayama Hosp, Dept Resp, Kita Ku, 2-1-1 Aoe, Okayama 7008607, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Bessho, Akihiro
Hosokawa, Shinobu
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机构:
Japanese Red Cross Okayama Hosp, Dept Resp, Kita Ku, 2-1-1 Aoe, Okayama 7008607, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Hosokawa, Shinobu
Fukamatsu, Nobuaki
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机构:
Japanese Red Cross Okayama Hosp, Dept Resp, Kita Ku, 2-1-1 Aoe, Okayama 7008607, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Fukamatsu, Nobuaki
Nakamura, Yukiko
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机构:
Yokohama Municipal Citizens Hosp, Dept Resp Med & Med Oncol, Hodogaya Ku, 56 Okazawa Cho, Yokohama, Kanagawa 2408555, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Nakamura, Yukiko
Kasai, Takashi
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机构:
Tochigi Canc Ctr, Div Thorac Oncol, 4-9-13 Yonan, Utsunomiya, Tochigi 3200834, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Kasai, Takashi
Sugiyama, Tomohide
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机构:
Tochigi Canc Ctr, Div Thorac Oncol, 4-9-13 Yonan, Utsunomiya, Tochigi 3200834, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
机构:
Teikyo Univ, Sch Med, Div Med Oncol, Dept Internal Med,Itabashi Ku, 2-11-1 Kaga, Tokyo 1730014, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Seki, Nobuhiko
Hamada, Akinobu
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机构:
Natl Canc Ctr, Div Mol Pharmacol, Res Inst, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Hamada, Akinobu
Okamoto, Hiroaki
论文数: 0引用数: 0
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机构:
Yokohama Municipal Citizens Hosp, Dept Resp Med & Med Oncol, Hodogaya Ku, 56 Okazawa Cho, Yokohama, Kanagawa 2408555, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan
Okamoto, Hiroaki
Masuda, Noriyuki
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机构:
Kitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, JapanKitasato Univ, Sch Med, Dept Resp Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan