Moxibustion for alleviating chemotherapy-induced gastrointestinal adverse effects: A systematic review of randomized controlled trials

被引:7
|
作者
Yao, Ziqian [1 ]
Xu, Zhongbo [2 ]
Xu, Tielong [1 ]
Liu, Xiaowu [1 ]
Xu, Sheng [1 ]
Wan, Chanjun [3 ]
Zhou, Xu [1 ]
机构
[1] Jiangxi Univ Chinese Med, Evidence based Med Res Ctr, Nanchang, Peoples R China
[2] Jiangxi Univ Chinese Med, Dept Emergency, Affiliated Hosp, Nanchang, Peoples R China
[3] Jiangxi Univ Chinese Med, Dept Cardiol, Affiliated Hosp, Nanchang, Peoples R China
关键词
Moxibustion; Gastrointestinal adverse effects; Chemotherapy; Malignant tumours; Systematic review; ULCERATIVE-COLITIS; ACUPUNCTURE; NAUSEA;
D O I
10.1016/j.ctcp.2021.101527
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Objective: This systematic review aims to assess whether moxibustion is effective and safe for gastrointestinal adverse effects, a common and thorny issue arising from chemotherapy. Methods: Seven electronic databases were searched up to August 28, 2021, to identify randomized controlled trials (RCTs) comparing moxibustion versus non-moxibustion treatments for various gastrointestinal adverse effects after chemotherapy. The Karnofsky performance status (KPS) and quality of life scores and the incidence of moxibustion-related adverse events were also investigated. Effects in meta-analyses were measured by risk ratios (RRs) or mean differences (MDs). Results: Thirty-two RCTs (n = 2990) were included. Compared to the controls, moxibustion significantly reduced the incidences of nausea/vomiting (RR 0.70, 95% CI 0.61-0.79), severe nausea/vomiting (RR 0.39, 95% CI 0.29-0.51), diarrhoea (RR 0.56, 95% CI 0.38-0.82), constipation (RR 0.59, 95% CI 0.44-0.78), and abdominal distension (RR 0.60, 95% CI 0.46-0.78). The KPS (MD 7.53, 95% CI 3.42-11.64) and quality of life (MD 8.88, 95% CI 0.96-16.80) scores were also significantly improved after moxibustion. The results did not support a benefit of moxibustion on inappetence (RR 0.69, 95% CI 0.40-1.22) or abdominal pain (RR 0.60, 95% CI 0.28-1.30). All adverse events related to moxibustion were mild. Conclusions: Moderate-to very-low-quality evidence suggests that moxibustion may be safely used as an adjuvant treatment after chemotherapy to reduce the incidences of nausea and vomiting, diarrhoea, constipation, and abdominal distension and improve the performance status and quality of life in patients with malignant tumours. Its effects on abdominal pain and inappetence are uncertain.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Moxibustion for the treatment of chemotherapy-induced leukopenia: a systematic review of randomized clinical trials
    Choi, Tae-Young
    Lee, Myeong Soo
    Ernst, Edzard
    SUPPORTIVE CARE IN CANCER, 2015, 23 (06) : 1819 - 1826
  • [2] Moxibustion for the treatment of chemotherapy-induced leukopenia: a systematic review of randomized clinical trials
    Tae-Young Choi
    Myeong Soo Lee
    Edzard Ernst
    Supportive Care in Cancer, 2015, 23 : 1819 - 1826
  • [3] The efficacy and safety of moxibustion for chemotherapy-induced gastrointestinal adverse reaction A protocol for systematic review and meta-analysis
    Zhang, Han-Xiao
    Zhang, Cheng-Shun
    Dai, Xiao-Qin
    Zuo, Chuan-Yi
    Lv, Peng
    Huang, Rui-Zhen
    Mo, Qian-Ning
    Bai, Yi-Feng
    Zhou, Yi
    MEDICINE, 2020, 99 (35)
  • [4] Effects of Ginger Intake on Chemotherapy-Induced Nausea and Vomiting: A Systematic Review of Randomized Clinical Trials
    Choi, Jihee
    Lee, Jounghee
    Kim, Kijoon
    Choi, Hyo-Kyoung
    Lee, Se-A
    Lee, Hae-Jeung
    NUTRIENTS, 2022, 14 (23)
  • [5] Chinese Herbal Medicine for Chemotherapy Induced Gastrointestinal Side Effects: A Systematic Review of Randomized Controlled Trials
    Chung-Wah Cheng
    Zhao-Xiang Bian
    Li-Dan Zhong
    Justin CY Wu
    Zhi-Xiu Lin
    Eric TC Ziea
    Vivian CW Wong
    WorldJournalofTraditionalChineseMedicine, 2017, 3 (02) : 31 - 50
  • [6] Effectiveness of moxibustion for exercise-induced fatigue—A systematic review for randomized controlled trials
    Da-ke Zhong
    Dan Tang
    Li Xue
    Jin Wen
    You-ping Li
    Chinese Journal of Integrative Medicine, 2016, 22 : 130 - 140
  • [7] Effectiveness of Moxibustion for Exercise-Induced Fatigue——A Systematic Review for Randomized Controlled Trials
    钟大可
    唐丹
    薛力
    文进
    李幼平
    Chinese Journal of Integrative Medicine, 2016, 22 (02) : 130 - 140
  • [8] Moxibustion for chemotherapy-induced myelosuppression: A systematic review and meta-analysis
    Wang, Xiao-Qing
    Qiao, Yue
    Zhang, Yuan -Yuan
    Yang, Li-Hua
    Duan, Pei-Bei
    EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE, 2023, 63
  • [9] Interventions for Preventing Chemotherapy-Induced Alopecia A Systematic Review and Network Meta-analysis of Randomized Controlled Trials
    Zhou, Tong
    Han, Shuyu
    Zhu, Zheng
    Hu, Yan
    Xing, Weijie
    CANCER NURSING, 2021, 44 (06) : E567 - E577
  • [10] Moxibustion for primary dysmenorrhea Protocol for a systematic review of randomized controlled trials
    Wu, Xiao
    Gan, Lu
    Zhang, Yong
    Chen, Bailu
    Luo, Jing
    Yan, Jue
    Chen, Guiquan
    MEDICINE, 2020, 99 (01)