Analysis of RT Sequences of Subtype C HIV-Type 1 Isolates from Indian Patients at Failure of a First-Line Treatment According to Clinical and/or Immunological WHO Guidelines

被引：14

作者：

Deshpande, Alaka ^{[2
,3
]}

Jeannot, Anne Cecile ^{[1
]}

Schrive, Marie Helene ^{[1
]}

Wittkop, Linda ^{[4
]}

Pinson, Patricia ^{[1
]}

Fleury, Herve J. ^{[1
]}

机构：

[1] Univ Bordeaux 2, Lab EA 2968, F-33076 Bordeaux, France

[2] Sir JJ Hosp, ART Ctr, Bombay, Maharashtra, India

[3] Sir JJ Hosp, Dept Internal Med, Bombay, Maharashtra, India

[4] Univ Bordeaux 2, INSERM, U897, F-33076 Bordeaux, France

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2010年 / 26卷 / 03期

关键词：

ANTIRETROVIRAL THERAPY; DRUG-RESISTANCE; TREATMENT-NAIVE; MUTATIONS; MUMBAI;

D O I：

10.1089/aid.2009.0217

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The reverse transcriptase (RT) sequences of HIV-1 subtype C isolates from Indian patients at failure ( according to WHO clinical or immunological criteria) of a first-line treatment including d4T/AZT-3TC-NVP/EFV were compared to those of HIV-1 isolates from naive patients and analyzed for drug resistance mutations (DRMs), which were interpreted according to ANRS and Stanford algorithms. All viruses were of subtype C. We have observed a decrease of the polymorphism at positions 36 and 214 of RT while D121Y, V179I, and Q217E could be new DRMs. Numerous crucial DRMs to NRTIs and NNRTIs could be recorded including TAMs of pathway 1 and K65R. According to both algorithms, the accumulation of DRMs may induce resistance to second-line NRTIs including tenofovir.

引用

页码：343 / 350

页数：8

共 11 条

[1] Resistance mutations in subtype CHIV type 1 isolates from Indian patients of mumbai receiving NRTIs plus NNRTIs and experiencing a treatment failure: Resistance to AR [J].

Deshpande, Alaka ;

Jauvin, Valerie ;

Magnin, Noel ;

Pinson, Patricia ;

Faure, Muriel ;

Masquelier, Bernard ;

Aurillac-Lavignolle, Valerie ;

Fleury, Herve J. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (02) :335-340

[2] Phylogenetic Analysis of HIV-1 Reverse Transcriptase Sequences from 382 Patients Recruited in JJ Hospital of Mumbai, India, between 2002 and 2008 [J].

Deshpande, Alaka ;

Jauvin, Valerie ;

Pinson, Patricia ;

Jeannot, Anne Cecile ;

Fleury, Herve J. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2009, 25 (06) :633-635

[3] Clinical and Genotypic Findings in HIV-Infected Patients With the K65R Mutation Failing First-Line Antiretroviral Therapy in Nigeria [J].

Hawkins, Claudia A. ;

Chaplin, Beth ;

Idoko, John ;

Ekong, Ernest ;

Adewole, Isaac ;

Gashau, Wadzani ;

Murphy, Robert L. ;

Kanki, Phyllis .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2009, 52 (02) :228-234

[4] Drug resistant mutations detected by genotypic drug resistance testing in patients failing therapy in clade C HIV-1 infected individuals from India [J].

Kandathil, A. J. ;

Kannangai, R. ;

Verghese, V. P. ;

Pulimood, S. A. ;

Rupali, P. ;

Sridharan, G. ;

Grant, P. ;

Pillay, D. ;

Abraham, O. C. .

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2009, 27 (03) :231-236

[5] High Frequency of Clinically Significant Mutations after First-Line Generic Highly Active Antiretroviral Therapy Failure: Implications for Second-Line Options in Resource-Limited Settings [J].

Kumarasamy, N. ;

Madhavan, Vidya ;

Venkatesh, Kartik K. ;

Saravanan, S. ;

Kantor, Rami ;

Balakrishnan, P. ;

Devaleenal, Bella ;

Poongulali, S. ;

Yepthomi, Tokugha ;

Solomon, Suniti ;

Mayer, Kenneth H. ;

Benson, Constance ;

Schooley, Robert .

CLINICAL INFECTIOUS DISEASES, 2009, 49 (02) :306-309

[6]

Martínez-Cajas JL, 2008, AIDS REV, V10, P212

[7]

MARTINEZCAJAS J, 2009, INT AIDS SOC, V12, P11

[8]

Orrell C, 2009, ANTIVIR THER, V14, P523

[9] HIV Type 1 Subtype C Drug Resistance among Pediatric and Adult South African Patients Failing Antiretroviral Therapy [J].

Pillay, Visva ;

Pillay, Candice ;

Kantor, Rami ;

Venter, Francois ;

Levin, Leon ;

Morris, Lynn .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2008, 24 (11) :1449-1454

[10] Human immunodeficiency virus type 1 drug resistance mutations in peripheral blood mononuclear cell proviral DNA among antiretroviral treatment-naive and treatment-experienced patients from Pune, India [J].

Sen, Sourav ;

Tripathy, Srikanth P. ;

Chimanpure, Vaishali M. ;

Patil, Ajit A. ;

Bagul, Rajani D. ;

Paranjape, Ramesh S. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (04) :489-497

← 1 2 →