BNP AND NGAL AS EARLY BIOMARKERS IN CARDIO-RENAL SYNDROME IN THE CRITICAL PATIENT

Introduction: Cardio-renal syndrome (CRS) is a combined disorder in which acute or chronic dysfunction of one of the organs causes acute or chronic dysfunction in the other. CRS affects 20-40% of patients in intensive care. Materials and methods: The study enrolled 27 patients hospitalized in the ICU of Catania's Gaspare Rodolico Polyclinic Hospital between April 2014 and May 2015. The patients were 18 to 8.5 years old, 15 females and 12 males, who were admitted to ICU with worsening of a chronic cardiovascular pathology, potentially classifiable as Type 1 or 2 CRS. Results: The study found that neutrophil gelatinase-associated lipocalin (NGAL) was able to predict acute renal damage and provided a risk stratification, and when B-type natriuretic peptide (BNP) was also used they increased the capacity to predict a clinical exacerbation. Conclusion: The findings confirmed that NGAL and BNP values are helpfitl biomarkers in the diagnosis and treatment of CRS.