Rehabilitation for a child with recalcitrant anti-N-methyl-D-aspartate receptor encephalitis: case report and literature review

被引:12
作者
Guo, Yao-Hong [1 ]
Kuan, Ta-Shen [1 ,2 ]
Hsieh, Pei-Chun [1 ]
Lien, Wei-Chih [1 ]
Chang, Chun-Kai [1 ]
Lin, Yu-Ching [1 ,2 ,3 ]
机构
[1] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Phys Med & Rehabil, Coll Med, Tainan 704, Taiwan
[2] Natl Cheng Kung Univ, Dept Phys Med & Rehabil, Coll Med, Tainan 704, Taiwan
[3] Natl Cheng Kung Univ, Med Device Innovat Ctr, Tainan 704, Taiwan
来源
NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2014年 / 10卷
关键词
anti-NMDA receptor encephalitis; autoimmune encephalitis; rehabilitation; cognition deficits; CASE SERIES; PATIENT;
D O I
10.2147/NDT.S74205
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is a newly recognized, potentially fatal, but treatable autoimmune disease. Good outcome predictors include milder severity of symptoms, no need for intensive care unit admission, early aggressive immunotherapy, and prompt tumor removal. We report a case of a young girl aged 3 years 2 months and diagnosed as recalcitrant anti-NMDA receptor encephalitis without any underlying neoplasm. The patient had initial symptoms of behavioral changes that progressed to generalized choreoathetosis and orofacial dyskinesia, which resulted in 6 months of hospitalization in the pediatric intensive care unit. One year after initial onset of the disease, she had only achieved the developmental age of an infant aged 6-8 months in terms of gross and fine motor skills, but she resumed total independence in activities of daily living after receiving extensive immunotherapy and 28 months of rehabilitation. Our brief review will help clinical practitioners become more familiar with this disease and the unique rehabilitation programs.
引用
收藏
页码:2263 / 2267
页数:5
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