Working in partnership to advance the 3Rs in toxicity testing

被引：42

作者：

Holmes, Anthony M. ^{[1
]}

Creton, Stuart ^{[1
]}

Chapman, Kathryn ^{[1
]}

机构：

[1] Natl Ctr Replacement Refinement & Reduct Anim Res, London W1B 1AL, England

来源：

TOXICOLOGY | 2010年 / 267卷 / 1-3期

关键词：

Acute toxicity; Safety testing; 3Rs; Toxicokinetics; Primates; Monoclonal antibodies; MONOCLONAL-ANTIBODIES; SKIN CORROSION; SAFETY; STRATEGIES;

D O I：

10.1016/j.tox.2009.11.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Toxicological assessment of pharmaceutical and non-pharmaceutical chemicals is a regulatory requirement to ensure all compounds likely to be exposed to humans or the environment are safe. These studies rely on the use of large numbers of animals and involve a number of assumptions and extrapolations that remain controversial in assuring consumer safety. The UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) has taken a collaborative approach to identify opportunities for implementation of the 3Rs principles (Replacement. Reduction and Refinement) to drive innovation and support animal welfare in toxicity testing. This review highlights the mechanisms by which the NC3Rs is working with the pharmaceutical and chemical industries and regulatory authorities to achieve these goals. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：14 / 19

页数：6

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