Efficacy and safety of lenvatinib in an elderly patient with metastatic papillary thyroid carcinoma and cardiological comorbidity: a case report

被引：0

作者：

Latorre, Agnese ^{[1
]}

Fioretti, Agnese Maria ^{[2
]}

Giotta, Francesco ^{[1
]}

Lorusso, Vito ^{[1
]}

机构：

[1] Ist Tumori G Paolo II, UO Oncol Med, Bari, Italy

[2] Ist Tumori G Paolo II, UO Dipartimentale Cardiol, Bari, Italy

来源：

FUTURE ONCOLOGY | 2019年 / 15卷 / 24S期

关键词：

cardiological comorbidity; lenvatinib; papillary thyroid cancer; tyrosine kinase inhibitor; ATRIAL-FIBRILLATION; CANCER; INHIBITOR; MANAGEMENT; INTERVAL; FOCUS; QT;

D O I：

10.2217/fon-2019-0114

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lenvatinib significantly prolonged progression-free survival versus placebo in patients with radio-iodine refractory differentiated thyroid carcinoma. However, the primary adverse effects of any grade that occurred in >40% of patients in the lenvatinib group of the Phase III SELECT trial was hypertension (67.8%). Therefore, this drug should be used with caution in patients with cardiological morbidity. Here, we describe the case of a 73-year-old man with hypertension, obesity and chronic atrial fibrillation, who received lenvatinib for 6 months in the absence of cardiological symptoms.

引用

页码：27 / 33

页数：7

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