Glucagon receptor knockout mice display increased insulin sensitivity and improved beta cell function

被引:0
作者
Sorensen, H
Brand, CL
Fosgerau, K
Gelling, RW
Nishimura, E
Ahren, B
机构
[1] Novo Nordisk AS, Discovery, Malov, Denmark
[2] Univ Washington, Dept Med, Seattle, WA USA
[3] Lund Univ, Dept Med, S-22100 Lund, Sweden
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
238
引用
收藏
页码:A91 / A91
页数:1
相关论文
共 50 条
  • [31] Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice
    Gelling, RW
    Du, XQ
    Dichmann, DS
    Romer, J
    Huang, H
    Cui, L
    Obici, S
    Tang, B
    Holst, JJ
    Fledelius, C
    Johansen, PB
    Rossetti, L
    Jelicks, LA
    Serup, P
    Nishimura, E
    Charron, MJ
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) : 1438 - 1443
  • [32] Glucagon receptor knockout mice are resistant to streptozotocin-induced β-cell loss and hyperglycemia
    Conarello, SL
    Li, Z
    Ronan, J
    Shelton, B
    Charron, MJ
    Zhang, BB
    DIABETES, 2004, 53 : A80 - A80
  • [33] INCREASED SENSITIVITY TO GLUCAGON IN INSULIN DEFICIENT DIABETIC SUBJECTS
    SCHADE, DS
    EATON, RP
    CLINICAL RESEARCH, 1976, 24 (01): : A30 - A30
  • [34] Selective reactivation of insulin receptor expression in insulin receptor knockout mice
    Okamoto, H
    Accili, D
    DIABETES, 2003, 52 : A314 - A314
  • [35] Impact of Vildagliptin on Glucose Tolerance, and beta Cell Mass in Insulin Receptor Substrate-2-Knockout Mice
    Sato, Koichiro
    Nakamura, Akinobu
    Shirakawa, Jun
    Muraoka, Tomonori
    Togashi, Yu
    Orime, Kazuki
    Terauchi, Yasuo
    DIABETES, 2011, 60 : A521 - A521
  • [36] Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia
    S. L. Conarello
    G. Jiang
    J. Mu
    Z. Li
    J. Woods
    E. Zycband
    J. Ronan
    F. Liu
    R. Sinha Roy
    L. Zhu
    M. J. Charron
    B. B. Zhang
    Diabetologia, 2007, 50 : 142 - 150
  • [37] Brain Mitochondrial Function and Cognition Are Impaired in Brain Insulin Receptor Knockout Mice
    Pataky, Mark W.
    Ruegsegger, Gregory
    Klaus, Katherine
    Starski, Phillip
    Nair, K. Sreekumaran
    DIABETES, 2020, 69
  • [38] Postnatal knockout of beta cell insulin receptor impaired insulin secretion in male mice exposed to high-fat diet stress
    Oakie, Amanda
    Zhou, Liangyi
    Rivers, Sydney
    Cheung, Christy
    Li, Jinming
    Wang, Rennian
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2020, 499
  • [39] Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice (vol 52, pg 2657, 2003)
    Minami, Asako
    Iseki, Masanori
    Kishi, Kazuhiro
    Wang, Miao
    Ogura, Makoto
    Furukawa, Noboru
    Hayashi, Sanae
    Yamada, Mizuki
    Obata, Toshiyuki
    Takeshita, Yukari
    Nakaya, Yutaka
    Bando, Yoshimi
    Izumi, Keisuke
    Moodie, Shonna A.
    Kajiura, Fumiko
    Matsumoto, Mitsuru
    Takatsu, Kiyoshi
    Takaki, Satoshi
    Ebina, Yousuke
    DIABETES, 2015, 64 (08) : 3050 - 3050
  • [40] Increased insulin sensitivity and glucose uptake in the hearts of stearoyl CoA desaturase 1 knockout mice
    Sampath, H
    Dobrzyn, A
    Ntambi, JM
    FASEB JOURNAL, 2005, 19 (04) : A829 - A830