Overexpression and increased DNA topoisomerase II-like enzyme activity in arsenite resistant Leishmania donovani

被引：8

作者：

Jayanarayan, KG ^{[1
]}

Dey, CS ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Biotechnol, Punjab 160062, India

来源：

MICROBIOLOGICAL RESEARCH | 2003年 / 158卷 / 01期

关键词：

topoisomerase II; Leishmania donovani; sodium arsenite resistance;

D O I：

10.1078/0944-5013-00177

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Western immunoblot analyses of whole cell lysates probed with a human specific monoclonal anti-topoisomerase Ilalpha antibody identified a 190 kDa protein over expressed in the arsenite resistant Leishmania donovani strain. The crude nuclear extract of the resistant strain showed higher topoisomerase II-like enzyme activity, suggesting a possible regulatory role of putative topoisomerase II in arsenite resistant Leishmania.

引用

页码：55 / 58

页数：4

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