Targeting key transcriptional factor STAT3 in colorectal cancer

被引：31
作者：
Chalikonda, Gayathri [1 ]
Lee, Hoomin [2 ]
Sheik, Aliya [2 ]
Huh, Yun Suk [2 ]
机构：
[1] Univ Nevada, Internal Med, Reno, NV 89502 USA
[2] Inha Univ, Dept Biol Engn, NanoBio High Tech Mat Res Ctr, Incheon 22212, South Korea
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2021年 / 476卷 / 09期
关键词：
Colorectal cancer; Transcription factors; STAT3; Inhibitors; COLON-CANCER; CELLS; CURCUMIN; SURVIVAL; PROLIFERATION; EGFR;
D O I：
10.1007/s11010-021-04156-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In developed countries, colorectal cancer (CRC) is the fourth most common cancer and the second leading cause of malignant-related deaths. CRC is treatable cancer when diagnosed early; however, diagnosis at the advanced stage is associated with a poor prognosis. Although chemotherapy is generally very promising, STAT3 protein which is overexpressed and persistently activated in CRC cells is observed to be the major contributor of chemoresistance development. It has been shown to play a prominent and pathogenic role in CRC initiation, progression, and metastasis. While over the past few years, research has been focused on STAT3 which is expressed at the center of various oncogenic pathways. This review is a discussion of the oncogenic role of STAT3 in CRC and potential therapeutic STAT3 inhibitors and analogs used to control and treat CRC.
引用
收藏
页码：3219 / 3228
页数：10
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