Syntheses, characterization and DNA-binding studies of ruthenium(II) terpyridine complexes:: [Ru(tpy)(PHBI)]2+ and [Ru(tpy)(PHNI)]2+

被引：94

作者：

Jiang, CW

Chao, H

Li, H

Ji, LN ^{[1
]}

机构：

[1] Zhongshan Univ, Sch Chem & Chem Engn, Guangzhou 510275, Peoples R China

[2] Guangxi Univ Tradit Chinese Med, Sch Pharm, Nanning 530001, Peoples R China

[3] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2003年 / 93卷 / 3-4期

基金：

中国国家自然科学基金;

关键词：

ruthenium(II) complex; polypyridine ligand; DNA binding;

D O I：

10.1016/S0162-0134(02)00577-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two novel tridentate ligands, 2-(2-benzimidazole)-1,10-phenanthroline (PHBI) and 2-(2-naphthoimidazole)-1,10-phenanthroline (PHNI), and their heteroleptic complexes [Ru(tpy)(PHBI)](ClO4)(2).2H(2)O (1) and [Ru(tpy)(PHNI)](CIO4)(2).H2O (2) (tpy=2,2':6',2"-terpyridyl) have been synthesized and characterized by elemental analysis, mass spectra, H-1 NMR, and electronic spectroscopy. The electrochemical behaviors of the two novel complexes were studied by cyclic voltammetry. The DNA-binding properties of the two complexes were investigated by spectroscopic methods and viscosity measurements. The results indicated that the two complexes interact with DNA in different binding modes. Complex 1 may bind to DNA via electrostatic interaction, while complex 2 binds to DNA by partial intercalation via the extended naphthyl ring into the base pairs of DNA. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：247 / 255

页数：9

共 49 条

[31]

Norden B, 1996, MET IONS BIOL SYST, V33, P177

[32] Binding of bimetallic 1,10-phenanthroline ruthenium(II) complexes to DNA [J].