Carbimazole-associated hypersensitivity vasculitis in a cat

被引:3
作者
Bowlt, K. [1 ]
Cattin, I. [1 ]
Stewart, J. [1 ]
机构
[1] Anim Hlth Trust, Newmarket CB8 7UU, Suffolk, England
关键词
D O I
10.1111/jsap.12154
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Feline hyperthyroidism can be treated medically, surgically or with radioactive iodine. Carbimazole inhibits both triiodothyronine and thyroxine synthesis in the thyroid gland and reported side effects include mild eosinophilia, leucopenia and lymphocytosis, thrombocytopenia, elevated liver enzyme activities, gastrointestinal signs and skin abnormalities. This case report describes a cat with carbimazole-associated apparent hypersensitivity vasculitis causing digital and tail necrosis, with multiple renal infarcts. Withdrawal of carbimazole resulted in stable disease.
引用
收藏
页码:643 / 647
页数:5
相关论文
共 17 条
[1]  
AUCOIN DP, 1985, J PHARMACOL EXP THER, V234, P13
[2]   Feline hyperthyroidism: spectrum of clinical presentions and response to carbimazole therapy [J].
Bucknell, DG .
AUSTRALIAN VETERINARY JOURNAL, 2000, 78 (07) :462-465
[3]  
Buijtels JJCWM, 2006, TIJDSCHR DIERGENEESK, V131, P478
[4]   Leukocytoclastic vasculilis and interstitial nephritis with carbimazole treatment [J].
Day, C ;
Bridger, J ;
Rylance, P ;
Jackson, M ;
Nicholas, J ;
Odum, J .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2003, 18 (02) :429-431
[5]  
DCruz D, 1995, BRIT J RHEUMATOL, V34, P1090
[6]  
Doyle Mittie K, 2003, Expert Opin Drug Saf, V2, P401, DOI 10.1517/eods.2.4.401.21423
[7]   Clinical efficacy and safety of a once-daily formulation of carbimazole in cats with hyperthyroidism [J].
Frenais, R. ;
Rosenberg, D. ;
Burgaud, S. ;
Horspool, L. J. I. .
JOURNAL OF SMALL ANIMAL PRACTICE, 2009, 50 (10) :510-515
[8]   Anti-thyroid drugs and antineutrophil cytoplasmic antibody positive vasculitis. A case report and review of the literature [J].
Gunton, JE ;
Stiel, J ;
Caterson, RJ ;
McElduff, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (01) :13-16
[9]   Case of propylthiouracil-induced ANCA associated small vessel vasculitis [J].
Harper, L ;
Cockwell, P ;
Savage, COS .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 1998, 13 (02) :455-458
[10]  
JANSSON R, 1983, INT J CLIN PHARM TH, V21, P505