Tissue-specific NK cell populations and their origin

被引：36

作者：

Lysakova-Devine, Tatyana ^{[1
]}

O'Farrelly, Cliona ^{[2
]}

机构：

[1] Dublin City Univ, Biomed Diagnost Inst, Dublin 9, Ireland

[2] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2014年 / 96卷 / 06期

基金：

爱尔兰科学基金会;

关键词：

natural killer cell progenitors; hematopoietic progenitors; innate immunity; lymphoid cells; NATURAL-KILLER-CELLS; HEMATOPOIETIC STEM-CELLS; INNATE LYMPHOID-CELLS; DELTA-T-CELLS; ROR-GAMMA-T; BONE-MARROW; PROGENITOR CELLS; SELF-RENEWAL; DEVELOPMENTAL PATHWAYS; HOST-DEFENSE;

D O I：

10.1189/jlb.1RU0514-241R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Review on the phenotype and function of tissue-specific NK cells suggesting some subpopulations differentiate in situ from tissue-resident hematopoietic stem cells. Tissue-specific NK cell subpopulations are found in adult gut, liver, and endometrium, as well as other sites in the body. Some differ phenotypically and functionally from pbNK cells, and their origin is disputed. In this review, we discuss tissue-specific NK cells and suggest that subpopulations differentiate in situ from tissue-resident hematopoietic progenitor cells. The understanding of the origins and maturation requirements of tissue-specific NK cells could lead to new classes of immunotherapy for organ-specific pathologies of infectious and malignant origin.

引用

页码：981 / 990

页数：10

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