Serologic Diagnosis of Rheumatoid Arthritis

被引：11

作者：

Allard-Chamard, Hugues ^{[1
,2
,3
,4
,5
]}

Boire, Gilles ^{[2
,3
,4
,5
]}

机构：

[1] MIT & Harvard, Ragon Inst MGH, Cambridge, MA USA

[2] Univ Sherbrooke, Fac Med & Hlth Sci, Div Rheumatol, Sherbrooke, PQ, Canada

[3] CHU Sherbrooke, Ctr Rech Clin, Sherbrooke, PQ, Canada

[4] CHU Sherbrooke, Ctr Integre Univ Sante, Div Rheumatol, CIUSSS Estrie CHUS, 3001,12th Ave North,Room 3853, Sherbrooke, PQ J1H 5N4, Canada

[5] CHU Sherbrooke, Serv Sociaux Estrie, CIUSSS Estrie CHUS, 3001,12th Ave North,Room 3853, Sherbrooke, PQ J1H 5N4, Canada

来源：

CLINICS IN LABORATORY MEDICINE | 2019年 / 39卷 / 04期

基金：

加拿大健康研究院;

关键词：

Rheumatoid arthritis; Rheumatoid factor; Anti-cyclic citrullinated peptide; Biomarkers; Serology; CITRULLINATED PROTEIN ANTIBODY; INTERNATIONAL REFERENCE PREPARATION; HISTIDINE-RICH GLYCOPROTEIN; IMMUNE-COMPLEXES; DISEASE ONSET; SA ANTIBODIES; NEPHELOMETRIC DETECTION; SENSITIVE MARKER; PEPTIDE; SERUM;

D O I：

10.1016/j.cll.2019.07.002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Accurate diagnosis of inflammatory arthritides remains a challenge because of substantial clinical overlap. To achieve a granular classification for informing clinical decisions, numerous potential serologic biomarkers have been identified. Rheumatologists have settled on rheumatoid factor and anti-citrullinated protein antibodies for the diagnosis of rheumatoid arthritis (RA) based on specificity and sensitivity and their ability to be integrated into clinical algorithms. These biomarkers should be interpreted in their specific clinical context. This article discusses the serologic basis for the diagnosis of RA, how these biomarkers have framed conceptualization of the pathogenesis of RA, and the inherent limitations in their use.

引用

页码：525 / +

页数：14

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