DEVELOPMENT OF RAPID UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF ZIPRASIDONE HYDROCHLORIDE IN BULK AND FORMULATIONS

Simple, sensitive, accurate, precise and rapid ultraviolet (UV) Spectrophotometric method was developed for the estimation of Ziprasidone HCl in pure form, formulations and stability samples. For the estimation of Ziprasidone HCl, solvent system employed was saline buffer pH 7.4 and wavelength of detection (lambda(det)) was 318nm. The developed method was used to estimate the total drug content in two commercially available oral formulations of Ziprasidone HCl and recovery studies were also carried out. Sample recovery in both the formulations using the above method was in good agreement with their respective label claims, thus suggesting the validity of the method and noninterference of formulation excipients in the estimation. The developed method was found to be stability specific and was validated as per ICH guidelines-2005, USP-2000 and statistical methods.