Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy

被引：117

作者：

Anderson, Mark C. ^{[1
,2
]}

Vonaesch, Pascale ^{[1
,2
]}

Saffarian, Azadeh ^{[1
,2
]}

Marteyn, Benoit S. ^{[1
,2
,3
]}

Sansonetti, Philippe J. ^{[1
,2
,4
]}

机构：

[1] Inst Pasteur, Unite Pathogenie Microbienne Mol, F-75724 Paris, France

[2] INSERM, U1202, Unite 1202, F-75015 Paris, France

[3] Inst Gustave Roussy, Lab Therapie Cellulaire, F-94800 Villejuif, France

[4] Coll France, F-75005 Paris, France

来源：

CELL HOST & MICROBE | 2017年 / 21卷 / 06期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

VI SECRETION SYSTEM; ESCHERICHIA-COLI; INTESTINAL MICROBIOTA; SALMONELLA; INFECTIONS; GUT; RESISTANCE; COLONIZATION; INFLAMMATION; COMPONENTS;

D O I：

10.1016/j.chom.2017.05.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Shigella is a leading cause of dysentery worldwide, with the majority of infections caused by two subgroups, S. flexneri and S. sonnei. Although S. flexneri has been highly prevalent in low-income countries, global development has brought an increase in S. sonnei at the expense of S. flexneri. However, the mechanisms behind this shift are not understood. Here we report that S. sonnei, but not S. flexneri, encodes a type VI secretion system (T6SS) that provides a competitive advantage in the gut. S. sonnei competes against E. coli and S. flexneri in mixed cultures, but this advantage is reduced in T6SS mutant strains. In addition, S. sonnei can persist as well as outcompete E. coli and S. flexneri in mice in a T6SS-dependent manner. These findings suggest that S. sonnei has a competitive advantage over S. flexneri and potentially explain the increasing global prevalence of S. sonnei.

引用

页码：769 / +

页数：11

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