Penicillanthone and penicillidic acids A-C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105

被引：14

作者：

Daengrot, Charuwan ^{[1
,2
]}

Rukachaisirikul, Vatcharin ^{[1
,2
]}

Tadpetch, Kwanruthai ^{[1
,2
]}

Phongpaichit, Souwalak ^{[3
,4
]}

Bowornwiriyapan, Kawitsara ^{[3
,4
]}

Sakayaroj, Jariya ^{[5
]}

Shen, Xu ^{[6
]}

机构：

[1] Prince Songkla Univ, Dept Chem, Hat Yai 90112, Thailand

[2] Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai 90112, Thailand

[3] Prince Songkla Univ, Nat Prod Res Ctr Excellence, Hat Yai 90112, Thailand

[4] Prince Songkla Univ, Dept Microbiol, Fac Sci, Hat Yai 90112, Thailand

[5] Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk, Khlong Luang 12120, Pathum Thani, Thailand

[6] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 46期

关键词：

DIPHENYL ETHER DERIVATIVES; XANTHONE DERIVATIVES; METABOLITES; BIOSYNTHESIS; BENZOPHENONE; PURPUROGENUM; AZAPHILONE; INHIBITORS; YO-2;

D O I：

10.1039/c6ra04401h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new xanthone (penicillanthone, 1) and three new diphenyl ether derivatives (penicillidic acids A-C, 2-4) together with 14 known compounds (5-18) were isolated from the soil-derived fungus Penicillium aculeatum PSU-RSPG105. The structures were elucidated by spectroscopic analyses. The absolute configuration of compound 1 was determined using the Snatzke's method whereas those of compounds 2-4 was established by comparison of their optical rotations with those of structurally related compounds. Compound 5 exhibited mild antimycobacterial activity against Mycobacterium tuberculosis with an MIC value of 25 mu g mL (1) and was noncytotoxic to noncancerous Vero cells. In addition, altenusin (12) displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 32 mu g mL(-1) and mild activity towards Vero cells with an IC50 value of 19.46 mu M.

引用

页码：39700 / 39709

页数：10

共 37 条

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