Similar binding to glutamate receptors by Rasmussen and partial epilepsy patients' sera

被引：25

作者：

Bernasconi, P

Cipelletti, B

Passerini, L

Granata, T

Antozzi, C

Mantegazza, R

Spreafico, R

机构：

[1] Ist Nazl Neurol Carlo Besta, Dept Expt Neurophysiol & Epilepsy, I-20133 Milan, Italy

[2] Ist Nazl Neurol Carlo Besta, Immunol & Muscular Pathol Unit, I-20133 Milan, Italy

[3] Ist Nazl Neurol Carlo Besta, Dept Child Neurol, I-20133 Milan, Italy

[4] Ist Nazl Neurol Carlo Besta, Dept Neuromuscular Dis, I-20133 Milan, Italy

来源：

NEUROLOGY | 2002年 / 59卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000036912.25881.7B

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Immunoreactivity of sera from patients with Rasmussen encephalitis (RE) and patients with partial epilepsy (PE) was analyzed by immunohistoblot on rat brain sections and the staining pattern compared with that obtained with antibodies to a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and NMDA receptors. Staining for anti-glutamate receptor 3 (GluR3) was found in 82% of patients with RE and 64% of patients with PE. Histoblot analysis showed a positive staining in GluR3- and NMDA-specific regions of rat brain, providing a comprehensive CNS immunolocalization.

引用

页码：1998 / 2001

页数：4

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