Targeting tumours with genetically enhanced T lymphocytes

被引:415
作者
Sadelain, M
Rivière, I
Brentjens, R
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10021 USA
关键词
D O I
10.1038/nrc971
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.
引用
收藏
页码:35 / 45
页数:11
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