Targeting tumours with genetically enhanced T lymphocytes

被引：414
作者：
Sadelain, M
Rivière, I
Brentjens, R
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10021 USA
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 01期
关键词：
D O I：
10.1038/nrc971
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.
引用
收藏
页码：35 / 45
页数：11
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