Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers

被引:49
作者
Zapardiel, Ignacio [1 ]
Cruz, Maria [2 ]
Diestro, Maria D. [1 ]
Requena, Antonio [2 ]
Garcia-Velasco, Juan A. [2 ,3 ]
机构
[1] La Paz Univ Hosp IdiPAZ, Gynaecol Oncol Unit, Paseo Castellana 261, Madrid 28046, Spain
[2] IVI Madrid, Madrid, Spain
[3] Rey Juan Carlos Univ, Madrid, Spain
关键词
fertility sparing; assisted reproductive techniques; gynaecological cancer; fertility preservation; oncological safety; ovarian cancer; cervical cancer; endometrial cancer; EPITHELIAL OVARIAN-CANCER; VAGINAL RADICAL TRACHELECTOMY; STAGE CERVICAL-CANCER; IN-VITRO FERTILIZATION; COMPLEX ATYPICAL HYPERPLASIA; MENOPAUSAL HORMONE-THERAPY; INTRACYTOPLASMIC SPERM INJECTION; EARLY ENDOMETRIAL ADENOCARCINOMA; LONG-TERM SURVIVAL; EXTENDED FOLLOW-UP;
D O I
10.1093/humupd/dmv066
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: The trend toward late childbearing has made fertility preservation a major issue for women who face gynecological cancer. New techniques in assisted reproductive medicine enable conception after primary treatment of these cancers. Here, we aimed to review the efficacy and safety of assisted reproductive techniques (ART) after fertility-preserving treatment of gynaecological cancers. METHODS: We conducted a systematic literature review of both prospective and retrospective studies in the PubMed, EMBASE, CENTRAL and SciSearch databases. In the retrieved studies, we evaluated live births, clinical pregnancies, overall survival and disease-free survival. RESULTS: We identified many prospective and retrospective studies on this topic, but no relevant randomized clinical trials. Fertility-sparing treatments with safe oncological outcomes are feasible in endometrial, cervical and ovarian cancer cases. After cancer treatment, ART seem safe and show variable obstetrical outcomes. CONCLUSIONS: After fertility-preserving treatment for gynaecological cancers, ART can enable pregnancy to be achieved with apparent oncological safety. The success of such procedures should directly impact clinical practice and management of those patients who require fertility-sparing treatment.
引用
收藏
页码:281 / 305
页数:25
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