EFFECT OF VENLAFAXINE AND NICOTINE ON THE LEVEL OF NEUROTRANSMITTERS AND THEIR METABOLITES IN RAT BRAINS

被引：0
作者：
Czubak, A. [1 ]
Nowakowska, E. [1 ]
Golembiowska, K. [2 ]
Kus, K. [1 ]
Burda, K. [1 ]
Metelska, J. [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Pharmacoecon & Social Pharm, PL-60529 Poznan, Poland
[2] Polish Acad Sci, Inst Pharmacol, Krakow, Poland
来源：
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2010年 / 61卷 / 03期
关键词：
venlafaxine; nicotine; neurotransmitters; microdialysis; noradrenaline; dopamine; hippocampus; COGNITIVE FUNCTION; ANTIDEPRESSANT; DEPRESSION; RECEPTORS; NORADRENALINE; THERAPEUTICS; INVOLVEMENT; RELEASE; HIPPOCAMPUS; IMIPRAMINE;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Nicotine (NIC) and venlafaxine (VEN) have been proved to exert antidepressant activity in both human and animals. The effect of antidepressant doses of NIC and VEN (our previous results) on noradrenergic (NA), dopaminergic (DA), serotoninergic (5-HT) neurotransmitters and their metabolites: DOPAC, HVA and 5-HIAA in rats' hippocainpus in freely moving rats were determined by microdialysis technique and HPLC method. Both drugs release 5-HT and NA, but VEN to a greater degree. DA level was affected only by VEN, however NIC extended the response of the DA system on VEN's effect. Combined administration of drugs caused the greatest changes in the 5-HT system. Both drugs contributed to reduction in neurotransmitter biotransformation.
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页码：339 / 346
页数：8
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