Differing profiles of face and scene discrimination deficits in semantic dementia and Alzheimer's disease

被引:50
作者
Lee, Andy C. H.
Levi, Netali
Davies, R. Rhys
Hodges, John R.
Graham, Kim S.
机构
[1] MRC, Cognit & Brain Sci Unit, Cambridge, England
[2] Univ Cambridge, Univ Neurol Unit, Cambridge, England
[3] Addenbrookes Hosp, Cambridge, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
memory; perception; dementia; medial temporal lobe; hippocampus; perirhinal cortex;
D O I
10.1016/j.neuropsychologia.2007.01.010
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Recent work in Alzheimer's disease (AD) and semantic dementia (SD) has reported a double dissociation in AD and SD on tests of visual discrimination, with poor performance on spatial tests in AD and impaired face discrimination in SD. This pattern has been attributed to the different patterns of atrophy seen in the medial temporal lobe (MTL) in these two neurodegenerative conditions. To investigate whether this functional distinction would extend to another task that employed different types of spatial and object stimuli, two groups of AD and SD patients were assessed on a simple test involving discriminations between blended stimuli. While neither group showed impairment when asked to discriminate objects and colour patches, the SD patients showed a selective deficit in the discrimination of faces whereas the AD patients had significant difficulties discriminating landscapes. These findings extend existing theoretical accounts of MTL function, and challenge current concepts of cognitive impairment in dementia. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2135 / 2146
页数:12
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